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Literature summary for 3.1.3.7 extracted from

  • Miyamoto, R.; Sugiura, R.; Kamitani, S.; Yada, T.; Lu, Y.; Sio, S.O.; Asakura, M.; Matsuhisa, A.; Shuntoh, H.; Kuno, T.
    Tol1, a fission yeast phosphomonoesterase, is an in vivo target of lithium, and its deletion leads to sulfite auxotrophy (2000), J. Bacteriol., 182, 3619-3625.
    View publication on PubMed
Search for more literature for 3.1.3.7

Activating Compound

Activating Compound Comment Organism Structure
K+
-
 Schizosaccharomyces pombe

Application

Application Comment Organism
medicine enzyme as a potential target of lithium therapy Schizosaccharomyces pombe

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Schizosaccharomyces pombe

Inhibitors

Inhibitors Comment Organism Structure
Li+
-
 Schizosaccharomyces pombe
Na+
-
 Schizosaccharomyces pombe

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.077
-
 inositol 1,4-bisphosphate pH 7.8, 30°C Schizosaccharomyces pombe

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Schizosaccharomyces pombe

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
40000
-
-
 Schizosaccharomyces pombe

Organism

Organism UniProt Comment Textmining
Schizosaccharomyces pombe
-
 KP767, KP812, KP656, KP801, KP803
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme Schizosaccharomyces pombe

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
adenosine 2',5'-bisphosphate + H2O
-
 Schizosaccharomyces pombe adenosine 5'-phosphate + phosphate
-
 ?
adenosine 3',5'-bisphosphate + H2O
-
 Schizosaccharomyces pombe adenosine 5'-phosphate + phosphate
-
 ?
inositol 1,3,4-trisphosphate + H2O
-
 Schizosaccharomyces pombe ?
-
 ?
inositol 1,4-bisphosphate + H2O
-
 Schizosaccharomyces pombe inositol 4-phosphate + phosphate
-
 ?