physiological function |
the baseline level of phosphatidylinositol-3,4,5-triphosphate influences cell susceptibility to the toxic effects of Aggregatibacter actinomycetemcomitans cytolethal distending toxin Cdt. Jurkat cells with known defects in phosphatidylinositol-3,4,5-triphosphate degradative enzymes, PTEN and SHIP1, contain high baseline levels of PIP3, pAkt, and pGSK3b, and also exhibit high sensitivity to Cdt-HUT78 cells, with no known defects in this pathway, contain low levels of PIP3, pAkt, and pGSK3b and exhibit reduced susceptibility to Cdt. Jurkat and HUT78 cells bind toxin at comparable levels and internalize relatively equal amounts of active subunit CdtB |
Aggregatibacter actinomycetemcomitans |