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Literature summary for 3.1.3.67 extracted from

  • Zhou, H.M.; Sun, Q.X.; Cheng, Y.
    Paeonol enhances the sensitivity of human ovarian cancer cells to radiotherapy-induced apoptosis due to downregulation of the phosphatidylinositol-3-kinase/Akt/phosphatase and tensin homolog pathway and inhibition of vascular endothelial growth factor (2017), Exp. Ther. Med., 14, 3213-3220 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine paeonol effectively enhances the sensitivity of ovarian cancer cells to radiation by significantly altering regulation of the proteins of the PI3K/Akt pathway, in addition to downregulating VEGF and HIF-1alpha Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P60484
-
-

Source Tissue

Source Tissue Comment Organism Textmining
OVCAR-3 cell
-
 Homo sapiens
-
SKOV-3 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
phosphatase and tensin homolog
-
 Homo sapiens
PTEN
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens treatment with flavonoid paeonol concentrations of 50 and 100 microM causes a significant downregulation of vascular endothelial growth factor VEGF, hypoxia inducible factor HIF-1alpha, and proteins of the phosphatidylinositol-3-kinase/Akt pathway down