Activating Compound | Comment | Organism | Structure |
---|---|---|---|
thrombin | transiently increases PTEN lipid phosphatase activity by about 2.5fold within 1 min, which remains elevated for 5 min | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
C124S | the PTEN mutant lacks phosphatase activity, but is not altered in TRPC6 activity | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate + H2O | Homo sapiens | - |
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
pulmonary artery endothelial cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate + H2O | - |
Homo sapiens | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
phosphatase and tensin homologue | - |
Homo sapiens |
PTEN | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | thrombin transiently increases PTEN lipid phosphatase activity, while pretreatment of HPAE cells with bpV(pic) slightly reduces basal PTEN activity.Thrombin fails to induce PTEN activity in cells pretreated with bpV(pic). Inhibiting PTEN activity also decreases Akt phosphorylation, inhibiting PTEN phosphatase activity has no effect on thrombin-induced Ca2+ entry | Homo sapiens |
physiological function | phosphatase and tensin homologue is a dual lipidprotein phosphatase that catalyzes the conversion of phosphoinositol 3,4,5-triphosphate to phosphoinositol 4,5-bisphosphate and thereby inhibits PI3K-Akt-dependent cell proliferation, migration, and tumor vascularization. But PTEN is indicated to play a role beyond suppressing PI3K signaling, it also plays a role in regulating Ca2+ entry through transient receptor potential canonical channel 6, TRPC6, that does not require PTEN phosphatase activity, overview. PTEN tail-domain residues 394-403 permit PTEN to associate with TRPC6. The inflammatory mediator thrombin promotes this association. Deletion of PTEN residues 394-403 prevents TRPC6 cell surface expression and Ca2+ entry, regulation, overview | Homo sapiens |