Cloned (Comment) | Organism |
---|---|
GFP-tagged wild-type, C124S and G129E mutant PTEN are constructed | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
C124S | PTEN mutant is devoid of phosphatase activity and fails to modulate p75NTR expression, indicating that phosphatase activity is required for PTEN regulation of neurotophin receptor p75NTR | Rattus norvegicus |
G129E | PTEN mutant which is lipid phosphatase dead but which retains protein phosphatase activity, significantly reduces the expression of p75NTR, suggesting that it is the protein phosphatase activity of PTEN that is able to regulate neurotophin receptor p75NTR expression | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Laminin | laminin medium induces PTEN upregulation decreases transcription factor Sp1-binding activity | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Rattus norvegicus | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | PTEN directly downregulates neurotophin receptor (p75NTR) expression by decreasing DNA-binding activity of transcription factor Sp1 | ? | - |
? | |
additional information | Rattus norvegicus | PTEN is a dual specificity phosphatase capable of dephosphorylating both lipid and protein substrates | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
PC-12 cell | pheochromocytoma cells | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | PTEN directly downregulates neurotophin receptor (p75NTR) expression by decreasing DNA-binding activity of transcription factor Sp1 | Rattus norvegicus | ? | - |
? | |
additional information | PTEN is a dual specificity phosphatase capable of dephosphorylating both lipid and protein substrates | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase | - |
Rattus norvegicus |
PTEN | - |
Rattus norvegicus |