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Literature summary for 3.1.3.67 extracted from

  • Goberdhan, D.C.I.; Wilson, C.
    PTEN: Tumour suppressor, multifunctional growth regulator and more (2003), Hum. Mol. Genet., 12, R239-R248.
No PubMed abstract available
Search for more literature for 3.1.3.67

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens germline PTEN mutations are associated with several dominant growth disorders. The growth regulatory function is primarily mediated via its lipid phosphatase activity, which specifically reduces the cellular levels of phosphatidylinositol 3,4,5-trisphosphate. This activity antagonizes the effects of activated phosphatidylinositol 3-kinase in the nutritionally controlled insulin receptor pathway, thereby reducing protein synthesis and restraining cell and organismal growth, while also regulating other biological processes, such as fertility and ageing. PTEN also plays a role as specialized cytoskeletal regulator, which, for example, is involved in directional movement of some migratory cells and may be important in metastasis ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
additional information the enzyme is mutated in a wide range of human cancers Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information germline PTEN mutations are associated with several dominant growth disorders. The growth regulatory function is primarily mediated via its lipid phosphatase activity, which specifically reduces the cellular levels of phosphatidylinositol 3,4,5-trisphosphate. This activity antagonizes the effects of activated phosphatidylinositol 3-kinase in the nutritionally controlled insulin receptor pathway, thereby reducing protein synthesis and restraining cell and organismal growth, while also regulating other biological processes, such as fertility and ageing. PTEN also plays a role as specialized cytoskeletal regulator, which, for example, is involved in directional movement of some migratory cells and may be important in metastasis Homo sapiens ?
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