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Literature summary for 3.1.3.66 extracted from

  • Zhang, M.; Suarez, E.; Vasquez, J.L.; Nathanson, L.; Peterson, L.E.; Rajapakshe, K.; Basil, P.; Weigel, N.L.; Coarfa, C.; Agoulnik, I.U.
    Inositol polyphosphate 4-phosphatase type II regulation of androgen receptor activity (2018), Oncogene, 38, 1121-1135 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine in prostate cancer cell lines INPP4B regulates androgen recetor transcriptional activity and the oncogenic signaling pathways Akt and PKC. In prostate cancer patient cohorts, a positive correlation between INPP4B expression and both androgen receptor mRNA levels and transcriptional output exists Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O15327
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Mus musculus Q6P1Y8
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Source Tissue

Source Tissue Comment Organism Textmining
LNCaP cell
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 Homo sapiens
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prostate gland
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 Mus musculus
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VCaP cell
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
INPP4B
-
 Mus musculus

General Information

General Information Comment Organism
physiological function INPP4B suppresses Akt and PKC signaling pathways and modulates androgen receptor transcriptional activity in normal mouse prostate. Tumor suppressor PTEN protein levels and phosphorylation of S380 are the same in Inpp4b-/- and wild-type males Mus musculus