Literature summary for 3.1.3.66 extracted from

Reed, D.E.; Shokat, K.M.
INPP4B and PTEN loss leads to PI-3,4-P2 accumulation and inhibition of PI3K in TNBC (2017), Mol. Cancer Res., 15, 765-775 .

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Application

Application	Comment	Organism
medicine	in Triple-negative breast cancer cells, which lack expression of estrogen receptor, progesterone receptor, and amplification of HER2/Neu, silencing isoform INPP4B decreases basal phospho-Akt (pAkt) and cellular proliferation, and in most cases sensitizes cells to phosphatidylinositol-3-kinase PI3K-alpha and PI3K-beta isoform-specific inhibitors. Overexpression of INPP4B desensitizes cells to PI3K inhibitors in a phosphatase activity-dependent manner	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O15327	-	-

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Release 2023.1 (January 2023)