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Literature summary for 3.1.3.66 extracted from
- Myeloid cell-specific inositol polyphosphate-4-phosphatase type I knockout mice impair bacteria clearance in a murine peritonitis model (2016), Innate Immun., 22, 444-451 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q9EPW0 | - |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| INPP4A | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | in myeloid cell-specific Inpp4a-conditional knockout mice, macrophages show increased Akt phosphorylation and reduced production of inflammatory cytokines in response to LPS or Escherichia coli in vitro. The Inpp4a knockout mice survive for a shorter time than wild type mice after i.p. infection with Escherichia coli, with less production of inflammatory cytokines. Escherichia coli clearance from blood and lung is significantly impaired in the knockout mice | Mus musculus |
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Release 2023.1 (January 2023)
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