Literature summary for 3.1.3.66 extracted from

Sharma, M.; Batra, J.; Mabalirajan, U.; Sharma, S.; Nagarkatti, R.; Aich, J.; Sharma, S.K.; Niphadkar, P.V.; Ghosh, B.
A genetic variation in inositol polyphosphate 4 phosphatase A enhances susceptibility to asthma (2008), Am. J. Respir. Crit. Care Med., 177, 712-719.

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Application

Application	Comment	Organism
medicine	INPP4A is identified as a novel asthma candidate gene	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	a nonsynonymous single nucleotide polymorphism +110832A/G (Thr/Ala) present within a PEST sequence (peptide sequence rich in proline, glutamic acid, serine and threonine), shows a significant association with atopic asthma. INPP4A alpha3 protein variant from platelets of individuals with AA genotype is found to be more susceptible to degradation, whereas the protein from individuals with GG genotype is less susceptible. Also, the basal levels of INPP4A protein in platelets from individuals with AA genotypes is found to be lower, suggesting poor stability in vivo as well	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q96PE3	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood platelet	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
inositol polyphosphate 4 phosphatase A	-	Homo sapiens
INPP4A	-	Homo sapiens

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Release 2023.1 (January 2023)