Literature summary for 3.1.3.64 extracted from

Lu, N.; Shen, Q.; Mahoney, T.R.; Neukomm, L.J.; Wang, Y.; Zhou, Z.
Two PI 3-kinases and one PI 3-phosphatase together establish the cyclic waves of phagosomal PtdIns(3)P critical for the degradation of apoptotic cells (2012), PLoS Biol., 10, e1001245.

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Organism

Organism	UniProt	Comment	Textmining
Caenorhabditis elegans	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
embryo	-	Caenorhabditis elegans	-

Synonyms

Synonyms	Comment	Organism
MTM-1	-	Caenorhabditis elegans

General Information

General Information	Comment	Organism
malfunction	inactivating mtm-1, blocks phagosome maturation	Caenorhabditis elegans
physiological function	MTM-1 antagonizes the activities of piki-1 (PI 3-kinase) and vps-34 (PI 3-kinase) on phagosomes	Caenorhabditis elegans
physiological function	MTM-1 down-regulates phagosomal PtdIns(3)P, this is demonstrated in mtm-1 mutant embryos where the level of the PtdIns(3)P on phagosomes is significantly higher than in wild-type embryos	Caenorhabditis elegans

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Release 2023.1 (January 2023)