Protein Variants | Comment | Organism |
---|---|---|
additional information | MTMR6 specifically inhibits the Ca2+-activated K+ channel, KCa3.1, by dephosphorylating phosphatidylinositol-3-phosphate. Chimeric MTMs containing both the MTMR6 coiled-coil (CC)(aa 512-621) and pleckstrin homology/GRAM (PH/G) (aa 1-106) domains function like MTMR6 to inhibit KCa3.1 channel activity, whereas chimeric MTMs containing either domain alone do not | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | immunofluorescent microscopy demonstrate that both the MTMR6 coiled-coil (CC)(aa 512-621) and pleckstrin homology/GRAM (PH/G) (aa 1-106) domains are required to co-localize MTMR6 to the plasma membrane with KCa3.1 | Homo sapiens | 5886 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
MTM | - |
Homo sapiens |
MTMR6 | - |
Homo sapiens |
myotubularin | - |
Homo sapiens |