Activating Compound | Comment | Organism | Structure |
---|---|---|---|
EDTA | optimum at 1.5-3 mM | Rattus norvegicus | |
EDTA | maximally active in the presence of EDTA | Rattus norvegicus | |
EGTA | activation, optimum at 1.5-3 mM | Rattus norvegicus | |
octyl glucoside | biphasic dependence of activity on octyl glucoside | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | in the millimolar range, 1 mM: 50-75% inhibition | Rattus norvegicus | |
Mg2+ | in the millimolar range, slightly less potent than Ca2+ | Rattus norvegicus | |
additional information | not inhibited by EDTA or EGTA | Rattus norvegicus | |
VO43- | 0.1 mM: 15% inhibition, 0.5 mM: 95% inhibition | Rattus norvegicus | |
Zn2+ | 0.5 mM: 90% inhibition | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Rattus norvegicus | 16020 | - |
soluble | soluble fraction | Rattus norvegicus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
additional information | no metal ion requirement | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidylinositol 3-phosphate + H2O | Rattus norvegicus | enzyme may terminate a metabolic signal or regulate precursor levels for other phosphatidylinositols that are phosphorylated in the D-3 position | phosphatidylinositol + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
NIH3T3 cell | fibroblast cells | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | not: phosphatidylinositol 4-phosphate, phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 1,3-bisphosphate | Rattus norvegicus | ? | - |
? | |
phosphatidylinositol 3-phosphate + H2O | specifically removes phosphate from the D-3-ring position of the substrate | Rattus norvegicus | phosphatidylinositol + phosphate | - |
? | |
phosphatidylinositol 3-phosphate + H2O | enzyme may terminate a metabolic signal or regulate precursor levels for other phosphatidylinositols that are phosphorylated in the D-3 position | Rattus norvegicus | phosphatidylinositol + phosphate | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | - |
about | Rattus norvegicus |
6.8 | - |
assay at | Rattus norvegicus |