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Literature summary for 3.1.3.62 extracted from
- Inositol 1,3,4,5,6-pentakisphosphate and inositol hexakisphosphate are inhibitors of the soluble inositol 1,3,4,5-tetrakisphosphate 3-phosphatase and the inositol 1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase from pig brain (1991), Biochem. J., 278, 219-224.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Ammonium phosphate buffer | 1 to 10 mM activates, higher concentrations are inhibitory | Sus scrofa |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ammonium phosphate buffer | 1 to 10 mM activates, higher concentrations are inhibitory | Sus scrofa | |
| Inositol 1,3,4,5,6-pentakisphosphate | strong, kinetics | Sus scrofa | |
| Inositol hexakisphosphate | more effective than inositol pentakisphosphate; strong, kinetics | Sus scrofa | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| soluble | - |
Sus scrofa | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| additional information | Mg2+-independent | Sus scrofa |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Sus scrofa | role in the metabolism of inositol phosphates, but probably no important participant in signal transduction | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Sus scrofa |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Sus scrofa | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O | - |
Sus scrofa | D-myo-inositol 1,4,5-trisphosphate + phosphate | - |
? | |
| additional information | role in the metabolism of inositol phosphates, but probably no important participant in signal transduction | Sus scrofa | ? | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Sus scrofa |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Sus scrofa |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.000003 | - |
Inositol hexakisphosphate | pH 7.4, 37°C | Sus scrofa | |
| 0.00006 | - |
Inositol 1,3,4,5,6-pentakisphosphate | pH 7.4, 37°C | Sus scrofa | |
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