Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.3.62 extracted from

  • Hughes, P.J.; Shears, S.B.
    Inositol 1,3,4,5,6-pentakisphosphate and inositol hexakisphosphate inhibit inositol-1,3,4,5-tetrakisphosphate 3-phosphatase in rat parotid glands (1990), J. Biol. Chem., 265, 9869-9875.
    View publication on PubMed
Search for more literature for 3.1.3.62

Inhibitors

Inhibitors Comment Organism Structure
Ammonium phosphate buffer not below 0.2 mM Rattus norvegicus
Endogenous heat-stable inhibitor
-
 Rattus norvegicus
Inositol 1,3,4,5,6-pentakisphosphate 0.001 mM, 50% inhibition; competitive; strong, kinetics Rattus norvegicus
inositol 1,3,4-trisphosphate 0.05 mM, about 50% inhibition Rattus norvegicus
Inositol 1,4,5-trisphosphate 0.05 mM, about 50% inhibition Rattus norvegicus
inositol 3,4,5,6-tetrakisphosphate 0.01 mM, 40% inhibition Rattus norvegicus
Inositol hexakisphosphate mixed inhibitor, 0.001 mM, 85% inhibition; more effective than inositol pentakisphosphate; strong, kinetics Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information kinetic data of the cytosolic enzyme Rattus norvegicus
0.007 0.008 D-myo-Inositol 1,3,4,5-tetrakisphosphate pH 7.2, 37°C, cytosolic enzyme Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Rattus norvegicus 5829
-
particle-bound
-
 Rattus norvegicus
-
-
soluble
-
 Rattus norvegicus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ Mg2+-dependent Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus inositol 1,3,4,5-tetrakisphosphate 3-phosphatase is unlikely to be an important activity in vivo ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
parotid gland
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
-
 Rattus norvegicus D-myo-inositol 1,4,5-trisphosphate + phosphate
-
 ?
additional information inositol 1,3,4,5-tetrakisphosphate 3-phosphatase is unlikely to be an important activity in vivo Rattus norvegicus ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
 assay at Rattus norvegicus