General Stability | Organism |
---|---|
dilution causes loss of activity | Leishmania donovani |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2'-deoxyadenosine 3'-phosphate | - |
Leishmania donovani | |
5'-AMP | - |
Leishmania donovani | |
ADP | - |
Leishmania donovani | |
ATP | - |
Leishmania donovani | |
dithiothreitol | - |
Leishmania donovani | |
EDTA | - |
Leishmania donovani | |
Zn2+ | - |
Leishmania donovani |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.17 | - |
3'-AMP | - |
Leishmania donovani | |
0.28 | - |
3'-IMP | - |
Leishmania donovani |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | - |
Leishmania donovani | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-AMP | Leishmania donovani | processing of exogenously available 3'-nucleotides into a form suitable for transport across the surface membrane of the parasite, which is incapable of purine biosynthesis de novo | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leishmania donovani | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Leishmania donovani |
Source Tissue | Comment | Organism | Textmining |
---|
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
2345 | - |
- |
Leishmania donovani |
Storage Stability | Organism |
---|---|
0°C, purified enzyme stable | Leishmania donovani |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-AMP | processing of exogenously available 3'-nucleotides into a form suitable for transport across the surface membrane of the parasite, which is incapable of purine biosynthesis de novo | Leishmania donovani | ? | - |
? | |
3'-AMP + H2O | 74% of the activity with 3'-IMP | Leishmania donovani | adenosine + phosphate | - |
? | |
3'-CMP + H2O | 6% of the activity with 3'-IMP | Leishmania donovani | cytosine + phosphate | - |
? | |
3'-GMP + H2O | 21% of the activity with 3'-IMP | Leishmania donovani | guanosine + phosphate | - |
? | |
3'-IMP + H2O | best substrate | Leishmania donovani | inosine + phosphate | - |
? | |
3'-UMP + H2O | 37% of the activity with 3'-IMP | Leishmania donovani | uridine + phosphate | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.5 | 7.5 | - |
Leishmania donovani |