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Literature summary for 3.1.3.57 extracted from

  • Inhorn, R.C.; Majerus, P.W.
    Inositol polyphosphate 1-phosphatase from calf brain. Purification and inhibition by Li+, Ca2+, and Mn2+ (1987), J. Biol. Chem., 262, 15946-15952.
    View publication on PubMed
Search for more literature for 3.1.3.57

Inhibitors

Inhibitors Comment Organism Structure
Ca2+
-
 Bos taurus
inositol 1,4-bisphosphate inositol 1,3,4-trisphosphate as substrate Bos taurus
Li+
-
 Bos taurus
Mn2+
-
 Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.004 0.005 inositol 1,4-bisphosphate 37°C, pH 7.5 Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Bos taurus 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
K+ activation, 0.05-0.1 M Bos taurus
Mg2+ kinetics Bos taurus
Mg2+ requirement Bos taurus
Na+ 0.05-0.1 M Bos taurus
Na+ activation Bos taurus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
44000
-
 gel filtration Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-myo-inositol 1,4-bisphosphate + H2O Bos taurus
-
 D-myo-inositol 4-phosphate + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
 calf
-

Purification (Commentary)

Purification (Comment) Organism
partial Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
12.4
-
 37°C, pH 7.5 Bos taurus

Storage Stability

Storage Stability Organism
-20°C, several months Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-myo-inositol 1,3,4-trisphosphate + H2O
-
 Bos taurus D-myo-inositol 3,4-bisphosphate + phosphate
-
 ?
D-myo-inositol 1,4-bisphosphate + H2O
-
 Bos taurus D-myo-inositol 4-phosphate + phosphate
-
 ?
additional information no substrate: inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate Bos taurus ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Bos taurus