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Literature summary for 3.1.3.57 extracted from
- Inositol polyphosphate 1-phosphatase from calf brain. Purification and inhibition by Li+, Ca2+, and Mn2+ (1987), J. Biol. Chem., 262, 15946-15952.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | - |
Bos taurus |  |
| inositol 1,4-bisphosphate | inositol 1,3,4-trisphosphate as substrate | Bos taurus | |
| Li+ | - |
Bos taurus | |
| Mn2+ | - |
Bos taurus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.004 | 0.005 | inositol 1,4-bisphosphate | 37°C, pH 7.5 | Bos taurus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Bos taurus | 5829 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| K+ | activation, 0.05-0.1 M | Bos taurus | |
| Mg2+ | requirement | Bos taurus | |
| Mg2+ | kinetics | Bos taurus | |
| Na+ | activation | Bos taurus | |
| Na+ | 0.05-0.1 M | Bos taurus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 44000 | - |
gel filtration | Bos taurus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-myo-inositol 1,4-bisphosphate + H2O | Bos taurus | - |
D-myo-inositol 4-phosphate + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
calf | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Bos taurus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 12.4 | - |
37°C, pH 7.5 | Bos taurus |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C, several months | Bos taurus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-myo-inositol 1,3,4-trisphosphate + H2O | - |
Bos taurus | D-myo-inositol 3,4-bisphosphate + phosphate | - |
? | |
| D-myo-inositol 1,4-bisphosphate + H2O | - |
Bos taurus | D-myo-inositol 4-phosphate + phosphate | - |
? | |
| additional information | no substrate: inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate | Bos taurus | ? | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Bos taurus |
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Release 2023.1 (January 2023)
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