Application | Comment | Organism |
---|---|---|
medicine | depletion of the inositol polyphosphate 5-phosphatase PIPP (INPP5J) increases breast cancer cell transformation, but reduces cell migration and invasion. PIPP ablation accelerates oncogene-driven breast cancer tumor growth in vivo, but reduces metastasis by regulating AKT1-dependent tumor cell migration. PIPP mRNA expression is reduced in human ER-negative breast cancers associated with reduced long-term outcome | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q15735 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
INPP5J | - |
Homo sapiens |
PIPP | - |
Homo sapiens |