Literature summary for 3.1.3.56 extracted from

Ooms, L.M.; Binge, L.C.; Davies, E.M.; Rahman, P.; Conway, J.R.; Gurung, R.; Ferguson, D.T.; Papa, A.; Fedele, C.G.; Vieusseux, J.L.; Chai, R.C.; Koentgen, F.; Price, J.T.; Tiganis, T.; Timpson, P.; McLean, C.A.; Mitchell, C.A.
The inositol polyphosphate 5-phosphatase PIPP regulates AKT1-dependent breast cancer growth and metastasis (2015), Cancer Cell, 28, 155-169.

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Application

Application	Comment	Organism
medicine	depletion of the inositol polyphosphate 5-phosphatase PIPP (INPP5J) increases breast cancer cell transformation, but reduces cell migration and invasion. PIPP ablation accelerates oncogene-driven breast cancer tumor growth in vivo, but reduces metastasis by regulating AKT1-dependent tumor cell migration. PIPP mRNA expression is reduced in human ER-negative breast cancers associated with reduced long-term outcome	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q15735	-	-

Synonyms

Synonyms	Comment	Organism
INPP5J	-	Homo sapiens
PIPP	-	Homo sapiens

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Release 2026.1 (March 2026)