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Literature summary for 3.1.3.56 extracted from

  • Tresaugues, L.; Silvander, C.; Flodin, S.; Welin, M.; Nyman, T.; Graeslund, S.; Hammarstroem, M.; Berglund, H.; Nordlund, P.
    Structural basis for phosphoinositide substrate recognition, catalysis, and membrane interactions in human inositol polyphosphate 5-phosphatases (2014), Structure, 22, 744-755.
    View publication on PubMed
Search for more literature for 3.1.3.56

Crystallization (Commentary)

Crystallization (Comment) Organism
sitting drop vapor diffusion method Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ contains Mg2+ Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O Homo sapiens
-
 1D-myo-inositol 1,3,4-trisphosphate + phosphate
-
 ?
1D-myo-inositol 3,4,5-trisphosphate + H2O Homo sapiens
-
 1D-myo-inositol 3,4-bisphosphate + phosphate
-
 ?
1D-myo-inositol 3,5-bisphosphate + H2O Homo sapiens
-
 1D-myo-inositol 3-phosphate + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O15357 isoform SHIP2
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
-
 Homo sapiens 1D-myo-inositol 1,3,4-trisphosphate + phosphate
-
 ?
1D-myo-inositol 3,4,5-trisphosphate + H2O
-
 Homo sapiens 1D-myo-inositol 3,4-bisphosphate + phosphate
-
 ?
1D-myo-inositol 3,5-bisphosphate + H2O
-
 Homo sapiens 1D-myo-inositol 3-phosphate + phosphate
-
 ?
additional information isofom SHIP2 is unable to dephosphorylate 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
inositol polyphosphate 5-phosphatase
-
 Homo sapiens
SHIP2
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function SHIP2 plays a role in negative regulation of insulin signaling and as a potential drug target for obesity and type 2 diabetes Homo sapiens