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Literature summary for 3.1.3.56 extracted from

  • Mills, S.J.; Vandeput, F.; Trusselle, M.N.; Safrany, S.T.; Erneux, C.; Potter, B.V.
    Benzene polyphosphates as tools for cell signalling: inhibition of inositol 1,4,5-trisphosphate 5-phosphatase and interaction with the pH domain of protein kinase Balpha (2008), ChemBioChem, 9, 1757-1766.
    View publication on PubMed
Search for more literature for 3.1.3.56

Inhibitors

Inhibitors Comment Organism Structure
3-benzyloxybenzene 1,2,4-trisphosphate
-
 Homo sapiens
3-hydroxybenzene 1,2,4-trisphosphate
-
 Homo sapiens
benzene 1,2,3,4-tetrakisphosphate
-
 Homo sapiens
benzene 1,2,3,5-tetrakisphosphate
-
 Homo sapiens
benzene 1,2,3-trisphosphate
-
 Homo sapiens
benzene 1,2,4,5-tetrakisphosphate
-
 Homo sapiens
benzene 1,2,4-trisphosphate
-
 Homo sapiens
benzene 1,2-bisphosphate
-
 Homo sapiens
benzene 1,3,5-trisphosphate
-
 Homo sapiens
biphenyl 2,3',4,5',6-pentakisphosphate
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens enzyme only binds soluble inositol polyphosphates ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme only binds soluble inositol polyphosphates Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
inositol 1,4,5-trisphosphate 5-phosphatase
-
 Homo sapiens
Ins(1,4,5)P3 5-phosphatase
-
 Homo sapiens
trisphosphate 5-phosphatase
-
 Homo sapiens
type I inositol-1,4,5-trisphosphate 5-phosphatase
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
additional information
-
 IC value is higher than 0.2 mM, IC50 value is obtained in the presence of 1 microM D-myo-inositol 1,4,5-trisphosphate as substrate Homo sapiens benzene 1,2-bisphosphate
0.001
-
 IC50 value is obtained in the presence of 1 microM D-myo-inositol 1,4,5-trisphosphate as substrate Homo sapiens biphenyl 2,3',4,5',6-pentakisphosphate
0.004
-
 IC50 value is obtained in the presence of 1 microM D-myo-inositol 1,4,5-trisphosphate as substrate Homo sapiens benzene 1,2,4,5-tetrakisphosphate
0.014
-
 potential mimic of D-myo-inositol 1,4,5-trisphosphate, IC50 value is obtained in the presence of 1 microM D-myo-inositol 1,4,5-trisphosphate as substrate Homo sapiens benzene 1,2,4-trisphosphate
0.016
-
 IC50 value is obtained in the presence of 1 microM D-myo-inositol 1,4,5-trisphosphate as substrate Homo sapiens benzene 1,3,5-trisphosphate
0.021
-
 IC50 value is obtained in the presence of 1 microM D-myo-inositol 1,4,5-trisphosphate as substrate Homo sapiens 3-hydroxybenzene 1,2,4-trisphosphate
0.068
-
 IC50 value is obtained in the presence of 1 microM D-myo-inositol 1,4,5-trisphosphate as substrate Homo sapiens 3-benzyloxybenzene 1,2,4-trisphosphate
0.078
-
 IC50 value is obtained in the presence of 1 microM D-myo-inositol 1,4,5-trisphosphate as substrate 6 Homo sapiens benzene 1,2,3,5-tetrakisphosphate
0.086
-
 IC50 value is obtained in the presence of 1 microM D-myo-inositol 1,4,5-trisphosphate as substrate Homo sapiens benzene 1,2,3-trisphosphate
0.098
-
 IC50 value is obtained in the presence of 1 microM D-myo-inositol 1,4,5-trisphosphate as substrate 6 Homo sapiens benzene 1,2,3,4-tetrakisphosphate