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Literature summary for 3.1.3.56 extracted from

  • Perera, I.Y.; Hung, C.Y.; Brady, S.; Muday, G.K.; Boss, W.F.
    A universal role for inositol 1,4,5-trisphosphate-mediated signaling in plant gravitropism (2006), Plant Physiol., 140, 746-760.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.56

Cloned(Commentary)

Cloned (Comment) Organism
functional expression of the enzyme in transgenic Arabidopsis thaliana plants using the Agrobacterium tumefaciens transfection system Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information construction of transgenic Arabidopsis thaliana plants expressing the human enzyme, the transgenic plants show no altered growth and life cycle phenotype although the basal level of inositol 1,4,5-trisphosphate is reduced by 90% compared to wild-type plants, but the plants are insensitive to gravitropic stimulation and show no increased InsP3 levels in inflorescence stem under gravistimulation in contrast to wild-type plants, bending responses, overview Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1D-myo-inositol 1,4,5-trisphosphate + H2O Homo sapiens specific for 1D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q14642
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 inositol 1,4,5-trisphosphate levels in transgenic Arabidopsis thaliana seedlings, roots and hypocotyls, expressing the recombinant enzyme Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1D-myo-inositol 1,4,5-trisphosphate + H2O specific for Homo sapiens 1D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
5PTase
-
 Homo sapiens
InsP 5-ptase
-
 Homo sapiens
type I inositol polyphosphate 5-phosphate
-
 Homo sapiens
type I inositol-1,4,5-trisphosphate 5-phosphatase
-
 Homo sapiens