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Literature summary for 3.1.3.56 extracted from

  • Harada, K.; Takeuchi, H.; Oike, M.; Matsuda, M.; Kanematsu, T.; Yagisawa, H.; Nakayama, K.I.; Maeda, K.; Erneux, C.; Hirata, M.
    Role of PRIP-1, a novel Ins(1,4,5)P3 binding protein, in Ins(1,4,5)P3-mediated Ca2+ signaling (2005), J. Cell. Physiol., 202, 422-433.
    View publication on PubMed
Search for more literature for 3.1.3.56

Cloned(Commentary)

Cloned (Comment) Organism
expression of His-tagged enzyme in Escherichia coli strain JM109 Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
protein PRIP-1 binding to PRIP-1, a Ins(1,4,5)P3-binding protein, inhibits the enzyme in vitro, in vivo binding of Ins(1,4,5)P3 to PRIP-1 prevents it from being hydrolyzed by the enzyme, PRIP-1 has a domain organization similar to phospholipase C-delta1, interaction analysis, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane associated Mus musculus 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ dependent on Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
48000
-
 x * 48000, recombinant His-tagged enzyme, SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1D-myo-inositol 1,4,5-trisphosphate + H2O Mus musculus the enzyme is involved in Ins(1,4,5)P3-mediated Ca2+ signaling associated to PRIP-1, a Ins(1,4,5)P3-binding protein, overview 1D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood platelet
-
 Mus musculus
-
brain
-
 Mus musculus
-
neuron cortical Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1D-myo-inositol 1,4,5-trisphosphate + H2O
-
 Mus musculus 1D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
1D-myo-inositol 1,4,5-trisphosphate + H2O the enzyme is involved in Ins(1,4,5)P3-mediated Ca2+ signaling associated to PRIP-1, a Ins(1,4,5)P3-binding protein, overview Mus musculus 1D-myo-inositol 1,4-bisphosphate + phosphate
-
 ?
additional information the enzyme binds to PRIP-1, a Ins(1,4,5)P3-binding protein, via the protein's PH-domain, which inhibits the enzyme activity Mus musculus ?
-
 ?

Subunits

Subunits Comment Organism
? x * 48000, recombinant His-tagged enzyme, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
5PTaseI
-
 Mus musculus
inositol polyphosphate 5-phosphatase
-
 Mus musculus