BRENDA - Enzyme Database show
show all sequences of 3.1.3.56

Purification and characterization of D-myo-inositol (1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase from skeletal muscle

Hansbro, P.M.; Foster, P.S.; Hogan, S.P.; Ozaki, S.; Denborough, M.A.; Arch. Biochem. Biophys. 311, 47-54 (1994)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
2,3-bisphosphoglycerate
-
Sus scrofa
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0011
-
D-myo-Inositol 1,3,4,5-tetrakisphosphate
type I enzyme, pH 7.5, 37°C
Sus scrofa
0.0089
-
D-myo-inositol 1,4,5-trisphosphate
type I enzyme, pH 7.5, 37°C
Sus scrofa
0.0714
-
D-myo-inositol 1,4,5-trisphosphate
type II enzyme, pH 7.5, 37°C
Sus scrofa
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
membrane
-
Sus scrofa
16020
-
soluble
83% of total activity; two different soluble enzymes, type I and type II
Sus scrofa
-
-
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Mg2+
-
Sus scrofa
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
48000
-
SDS-PAGE, type I enzyme
Sus scrofa
81000
-
gel filtration, type II enzyme
Sus scrofa
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
Sus scrofa
-
D-myo-inositol 1,3,4-trisphosphate + phosphate
-
-
-
D-myo-inositol 1,4,5-trisphosphate + H2O
Sus scrofa
involved in regulation of excitation-contraction coupling in skeletal muscle
D-myo-inositol 1,4-bisphosphate + phosphate
-
Sus scrofa
?
D-myo-inositol 1,4,5-trisphosphate + H2O
Sus scrofa
regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
D-myo-inositol 1,4-bisphosphate + phosphate
-
Sus scrofa
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Sus scrofa
-
-
-
Purification (Commentary)
Commentary
Organism
type I enzyme
Sus scrofa
Source Tissue
Source Tissue
Commentary
Organism
Textmining
muscle
skeletal muscle
Sus scrofa
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
2.54
-
purified type I enzyme, pH 7.5, 37°C
Sus scrofa
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
-
646391
Sus scrofa
D-myo-inositol 1,3,4-trisphosphate + phosphate
-
-
-
-
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
type I and type II enzyme
646391
Sus scrofa
D-myo-inositol 1,3,4-trisphosphate + phosphate
-
-
-
-
D-myo-inositol 1,4,5-trisphosphate + H2O
-
646391
Sus scrofa
D-myo-inositol 1,4-bisphosphate + phosphate
-
646391
Sus scrofa
?
D-myo-inositol 1,4,5-trisphosphate + H2O
involved in regulation of excitation-contraction coupling in skeletal muscle
646391
Sus scrofa
D-myo-inositol 1,4-bisphosphate + phosphate
-
646391
Sus scrofa
?
D-myo-inositol 1,4,5-trisphosphate + H2O
regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
646391
Sus scrofa
D-myo-inositol 1,4-bisphosphate + phosphate
-
646391
Sus scrofa
?
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
2,3-bisphosphoglycerate
-
Sus scrofa
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0011
-
D-myo-Inositol 1,3,4,5-tetrakisphosphate
type I enzyme, pH 7.5, 37°C
Sus scrofa
0.0089
-
D-myo-inositol 1,4,5-trisphosphate
type I enzyme, pH 7.5, 37°C
Sus scrofa
0.0714
-
D-myo-inositol 1,4,5-trisphosphate
type II enzyme, pH 7.5, 37°C
Sus scrofa
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
membrane
-
Sus scrofa
16020
-
soluble
83% of total activity; two different soluble enzymes, type I and type II
Sus scrofa
-
-
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Mg2+
-
Sus scrofa
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
48000
-
SDS-PAGE, type I enzyme
Sus scrofa
81000
-
gel filtration, type II enzyme
Sus scrofa
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
Sus scrofa
-
D-myo-inositol 1,3,4-trisphosphate + phosphate
-
-
-
D-myo-inositol 1,4,5-trisphosphate + H2O
Sus scrofa
involved in regulation of excitation-contraction coupling in skeletal muscle
D-myo-inositol 1,4-bisphosphate + phosphate
-
Sus scrofa
?
D-myo-inositol 1,4,5-trisphosphate + H2O
Sus scrofa
regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
D-myo-inositol 1,4-bisphosphate + phosphate
-
Sus scrofa
?
Purification (Commentary) (protein specific)
Commentary
Organism
type I enzyme
Sus scrofa
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
muscle
skeletal muscle
Sus scrofa
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
2.54
-
purified type I enzyme, pH 7.5, 37°C
Sus scrofa
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
-
646391
Sus scrofa
D-myo-inositol 1,3,4-trisphosphate + phosphate
-
-
-
-
D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O
type I and type II enzyme
646391
Sus scrofa
D-myo-inositol 1,3,4-trisphosphate + phosphate
-
-
-
-
D-myo-inositol 1,4,5-trisphosphate + H2O
-
646391
Sus scrofa
D-myo-inositol 1,4-bisphosphate + phosphate
-
646391
Sus scrofa
?
D-myo-inositol 1,4,5-trisphosphate + H2O
involved in regulation of excitation-contraction coupling in skeletal muscle
646391
Sus scrofa
D-myo-inositol 1,4-bisphosphate + phosphate
-
646391
Sus scrofa
?
D-myo-inositol 1,4,5-trisphosphate + H2O
regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate
646391
Sus scrofa
D-myo-inositol 1,4-bisphosphate + phosphate
-
646391
Sus scrofa
?
Other publictions for EC 3.1.3.56
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
730981
Braun
Membrane interaction and funct ...
Homo sapiens
Structure
22
664-666
2014
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
730984
Tresaugues
Structural basis for phosphoin ...
Homo sapiens
Structure
22
744-755
2014
-
-
-
1
-
-
-
-
-
1
-
3
-
1
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
3
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
729621
Wang
Inositol polyphosphate 5-phosp ...
Arabidopsis thaliana
Development
139
2221-2233
2012
-
-
-
-
-
-
-
-
-
-
-
1
-
3
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
1
2
2
1
-
-
706152
Khodakovskaya
Increasing inositol (1,4,5)-tr ...
Homo sapiens
Plant Biotechnol. J.
8
170-183
2010
-
-
1
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
700488
Siddique
Myo-inositol oxygenase genes a ...
Arabidopsis thaliana
New Phytol.
184
457-472
2009
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
691787
Mills
Benzene polyphosphates as tool ...
Homo sapiens
ChemBioChem
9
1757-1766
2008
-
-
-
-
-
-
10
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
10
-
-
-
-
-
-
-
10
10
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
694699
Ercetin
A phosphatidylinositol phospha ...
Arabidopsis thaliana
Plant Mol. Biol.
67
375-388
2008
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
682411
Gunesekera
Inositol polyphosphate 5-phosp ...
Arabidopsis thaliana
Plant Physiol.
143
1408-1417
2007
-
1
-
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
10
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
682680
Wohlkoenig
Expression and purification in ...
Homo sapiens
Protein Expr. Purif.
55
69-74
2007
-
-
-
-
-
-
-
-
-
1
1
-
-
3
-
-
1
-
-
-
1
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
1
-
-
1
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
666645
Perera
A universal role for inositol ...
Homo sapiens
Plant Physiol.
140
746-760
2006
-
-
1
-
1
-
-
-
-
1
-
1
-
4
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
679206
Mills
3-hydroxybenzene 1,2,4-trispho ...
Homo sapiens
Chembiochem
7
1696-1706
2006
-
-
-
-
-
-
2
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
3
-
1
-
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
2
2
-
-
-
-
-
-
-
-
-
-
-
1
-
-
3
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
665810
Harada
Role of PRIP-1, a novel Ins(1, ...
Mus musculus
J. Cell. Physiol.
202
422-433
2005
-
-
1
-
-
-
1
-
1
1
1
1
-
1
-
-
-
-
-
3
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
1
1
1
-
-
-
-
-
3
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
663839
Horne
D-6-Deoxy-myo-inositol 1,3,4,5 ...
Rattus norvegicus
Biochem. Biophys. Res. Commun.
320
1262-1270
2004
-
-
-
-
-
-
1
-
1
1
-
1
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
1
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
665575
Chi
Comparative mechanistic and su ...
Homo sapiens, Schizosaccharomyces pombe
J. Biol. Chem.
279
44987-44995
2004
-
-
2
-
1
-
2
3
-
5
-
2
-
2
-
-
2
2
-
-
-
-
23
1
2
-
-
1
2
1
-
-
1
-
-
-
-
2
-
-
1
-
-
2
1
3
-
5
-
2
-
-
-
2
-
-
-
-
23
1
2
-
-
1
2
1
-
-
-
-
-
-
-
-
665580
Seeds
A molecular basis for inositol ...
Drosophila melanogaster
J. Biol. Chem.
279
47222-47232
2004
-
-
-
-
-
-
-
-
-
-
-
3
-
7
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
666585
Zhong
Molecular and biochemical char ...
Arabidopsis thaliana
Plant Cell Physiol.
45
1720-1728
2004
1
-
1
-
-
-
-
1
-
1
-
2
-
2
-
-
1
-
-
6
-
-
6
1
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
2
-
2
-
2
-
-
-
2
-
11
-
-
6
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646404
Burnette
An Arabidopsis inositol 5-phos ...
Arabidopsis sp.
Plant Physiol.
132
1011-1019
2003
-
-
1
-
-
-
-
-
-
-
1
1
-
2
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646403
Whisstock
The structure and function of ...
Homo sapiens
IUBMB Life
53
15-23
2002
-
-
-
-
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646401
DePass
Inositol 1,4,5 trisphosphate i ...
Tradescantia virginiana
Planta
213
518-524
2001
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646402
Tsujishita
Specificity determinants in ph ...
Schizosaccharomyces pombe
Cell
105
379-389
2001
-
-
1
1
1
-
-
1
-
-
-
2
-
1
-
-
1
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
1
-
-
-
-
1
-
-
-
2
-
-
-
1
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646400
Whisstock
The inositol polyphosphate 5-p ...
Mus musculus, Saccharomyces cerevisiae
J. Biol. Chem.
275
37055-37061
2000
-
-
2
-
15
-
-
-
-
2
1
2
-
2
-
-
2
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
15
-
-
-
-
-
-
2
1
2
-
-
-
2
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646399
Mochizuki
Novel inositol polyphosphate 5 ...
Rattus norvegicus
J. Biol. Chem.
274
36790-36795
1999
-
-
1
-
4
-
-
-
2
-
1
2
-
1
-
1
-
-
-
8
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
4
-
-
-
-
-
2
-
1
2
-
-
1
-
-
8
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646398
Erneux
The diversity and possible fun ...
Homo sapiens
Biochim. Biophys. Acta
1436
185-199
1998
-
-
-
-
-
-
3
-
2
1
-
2
-
1
-
1
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
2
1
-
2
-
-
1
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646397
De Smedt
Isoprenylated human brain type ...
Homo sapiens
J. Biol. Chem.
272
17367-17375
1997
-
-
1
-
1
-
-
-
1
-
-
2
-
3
-
1
-
-
-
4
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
2
-
-
1
-
-
4
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646395
De Smedt
Post-translational modificatio ...
Homo sapiens, Rattus norvegicus
J. Biol. Chem.
271
10419-10424
1996
-
-
1
-
2
-
-
-
4
-
1
2
-
4
-
1
1
-
-
2
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
4
-
1
2
-
-
1
1
-
2
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646396
Communi
Arginine 343 and 350 are two a ...
Homo sapiens
J. Biol. Chem.
271
11676-11683
1996
-
-
1
-
2
-
2
3
-
-
1
1
-
2
-
-
1
-
-
-
3
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
2
-
3
-
-
1
1
-
-
-
1
-
-
3
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646393
Jefferson
Properties of type II inositol ...
Homo sapiens
J. Biol. Chem.
270
9370-9377
1995
-
-
1
-
1
-
-
-
-
-
-
3
-
1
-
1
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
3
-
-
1
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646394
Carrasco
-
Inositol 1,4,5-triphosphate 3- ...
Frog
Comp. Biochem. Physiol. B
110B
747-753
1995
-
-
-
-
-
-
3
-
-
-
-
1
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
586935
Wang
Studies on the properties of m ...
Bos taurus
Biochim. Biophys. Acta
1222
27-36
1994
-
-
-
-
-
-
5
1
2
2
-
1
-
2
-
1
-
-
-
3
-
-
2
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
1
2
2
-
1
-
-
1
-
-
3
-
-
2
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
646374
Verjans B.; De Smedt
-
Cloning and expression in E. c ...
Bos taurus, Canis lupus familiaris
Biochem. J.
300
85-90
1994
-
-
1
-
-
-
3
2
-
-
2
4
-
2
-
-
1
-
-
2
1
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
3
-
2
-
-
2
4
-
-
-
1
-
2
1
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646387
Lynch
Characterisation and Ca(2+)-de ...
Bos taurus
Biochem. Soc. Trans.
22
314S
1994
-
-
-
-
-
-
1
2
2
1
-
1
-
2
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
2
2
1
-
1
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646388
Van Dijken
Phosphorylation of inositol 1, ...
Bos taurus
Eur. J. Biochem.
226
561-566
1994
-
-
-
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
1
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646389
Safrany
Design of potent and selective ...
Homo sapiens, Rattus norvegicus
Biochemistry
33
10763-10769
1994
-
1
-
-
-
-
8
-
-
-
-
2
-
4
-
-
-
-
-
2
-
-
4
-
-
-
-
-
-
-
-
-
4
-
-
-
1
-
-
-
-
-
-
8
4
-
-
-
-
2
-
-
-
-
-
2
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646391
Hansbro
Purification and characterizat ...
Sus scrofa
Arch. Biochem. Biophys.
311
47-54
1994
-
-
-
-
-
-
1
3
2
1
2
3
-
1
-
-
1
-
-
1
1
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
3
2
1
2
3
-
-
-
1
-
1
1
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646392
Hodgkin
Bovine testis and human erythr ...
Bos taurus, Homo sapiens
Biochem. J.
297
637-645
1994
-
-
-
-
-
1
1
2
2
-
3
4
-
2
-
-
2
-
-
3
2
2
8
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
2
2
-
3
4
-
-
-
2
-
3
2
2
8
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646386
Verjans
Purification of bovine brain i ...
Bos taurus
Eur. J. Biochem.
204
1083-1087
1992
-
-
-
-
-
-
-
1
1
-
1
1
-
2
-
-
1
-
-
1
1
-
2
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
1
1
-
-
-
1
-
1
1
-
2
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
646383
Hollande
Regeneration of soluble and pa ...
Bos taurus
Biochem. J.
277
293-294
1991
-
-
-
-
-
-
-
-
2
-
1
2
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
1
2
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646384
Höer
Inositol 1,3,4,5,6-pentakispho ...
Sus scrofa
Biochem. J.
278
219-224
1991
-
-
-
-
-
-
3
-
-
-
-
2
-
2
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
3
4
-
-
-
-
2
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646385
Hodgkin
Generation of plasma membrane ...
Bos taurus, Homo sapiens, Ovis aries, Sus scrofa
Biochem. Soc. Trans.
19
1055
1991
-
-
-
-
-
-
-
-
8
-
-
4
-
4
-
-
1
-
-
4
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
8
-
-
4
-
-
-
1
-
4
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646381
Hughes
Inositol 1,3,4,5,6-pentakispho ...
Rattus norvegicus
J. Biol. Chem.
265
9869-9875
1990
-
-
-
-
-
-
-
1
1
-
-
2
-
1
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
2
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646382
Fowler
Kinetic and inhibitor profiles ...
Homo sapiens, Rattus norvegicus
Biochem. J.
271
735-742
1990
-
-
-
-
-
-
14
-
4
-
-
2
-
3
-
-
-
-
-
1
-
-
4
-
-
-
-
-
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
14
-
-
4
-
-
2
-
-
-
-
-
1
-
-
4
-
-
-
-
-
2
2
-
-
-
-
-
-
-
-
646373
Erneux
Soluble and particulate Ins(1, ...
Bos taurus
Eur. J. Biochem.
181
317-322
1989
-
-
-
-
-
-
-
2
2
-
5
2
-
2
-
-
1
-
-
2
1
1
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
2
-
5
2
-
-
-
1
-
2
1
1
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646379
Mitchell
Identification and isolation o ...
Homo sapiens
J. Biol. Chem.
264
8873-8877
1989
-
-
-
-
-
-
4
2
1
2
1
2
-
2
-
1
1
-
-
1
1
-
5
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
4
2
2
1
2
1
2
-
-
1
1
-
1
1
-
5
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646380
Lemos
Identification of the bovine b ...
Bos taurus
FEBS Lett.
249
321-323
1989
-
-
-
-
-
-
2
-
1
-
2
1
-
2
-
-
1
-
-
2
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
2
1
-
-
-
1
-
2
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646378
Milani
D-myo-Inositol 1,4,5-trisphosp ...
Frog, Oryctolagus cuniculus
Biochem. J.
254
525-529
1988
-
-
-
-
-
-
9
2
2
-
-
3
-
2
-
-
-
-
-
4
5
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
9
-
2
2
-
-
3
-
-
-
-
-
4
5
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646375
Kirk
Inositol trisphosphate and tet ...
Rattus norvegicus
Biochem. Soc. Trans.
15
28-32
1987
-
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646376
Hansen
Purification and characterizat ...
Rattus norvegicus
J. Biol. Chem.
262
17319-17326
1987
-
-
-
-
-
-
10
3
1
2
2
2
-
2
-
-
1
-
-
2
2
1
5
1
-
-
-
-
2
1
-
-
1
-
-
-
-
-
-
-
-
-
-
10
1
3
1
2
2
2
-
-
-
1
-
2
2
1
5
1
-
-
-
-
2
1
-
-
-
-
-
-
-
-
646377
Connolly
The metabolism of tris- and te ...
Homo sapiens
J. Biol. Chem.
262
2146-2149
1987
-
-
-
-
-
-
1
2
-
-
-
2
-
1
-
1
1
-
-
1
-
-
4
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
2
-
-
-
2
-
-
1
1
-
1
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
646372
Downes
The inositol trisphosphate pho ...
Homo sapiens
Biochem. J.
203
169-177
1982
-
-
-
-
-
-
6
1
2
3
-
1
-
2
-
-
-
-
-
2
1
-
3
-
-
-
-
-
1
1
-
-
1
-
-
-
-
-
-
-
-
-
-
6
1
1
2
3
-
1
-
-
-
-
-
2
1
-
3
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-