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Literature summary for 3.1.3.56 extracted from
- Inositol 1,3,4,5,6-pentakisphosphate and inositol hexakisphosphate are inhibitors of the soluble inositol 1,3,4,5-tetrakisphosphate 3-phosphatase and the inositol 1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase from pig brain (1991), Biochem. J., 278, 219-224.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ammonium phosphate | - |
Sus scrofa |  |
| Inositol 1,3,4,5,6-pentakisphosphate | - |
Sus scrofa | |
| Inositol hexakisphosphate | competitive | Sus scrofa | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O | Sus scrofa | product is precursor for inositol 1,3,4,5,6-pentiskphosphate via inositol 1,3,4,6-tetraiskphosphate | D-myo-inositol 1,3,4-trisphosphate + phosphate | - |
? | |
| D-myo-inositol 1,4,5-trisphosphate + H2O | Sus scrofa | - |
D-myo-inositol 1,4-bisphosphate + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Sus scrofa | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O | - |
Sus scrofa | D-myo-inositol 1,3,4-trisphosphate + phosphate | - |
? | |
| D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O | product is precursor for inositol 1,3,4,5,6-pentiskphosphate via inositol 1,3,4,6-tetraiskphosphate | Sus scrofa | D-myo-inositol 1,3,4-trisphosphate + phosphate | - |
? | |
| D-myo-inositol 1,4,5-trisphosphate + H2O | - |
Sus scrofa | D-myo-inositol 1,4-bisphosphate + phosphate | - |
? | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.01 | - |
Inositol hexakisphosphate | with inositol 1,4,5-trisphosphate as substrate | Sus scrofa | |
| 0.015 | - |
Inositol hexakisphosphate | with inositol 1,3,4,5-tetrakisphosphate as substrate | Sus scrofa | |
| 0.02 | - |
Inositol 1,3,4,5,6-pentakisphosphate | with inositol 1,4,5-trisphosphate as substrate | Sus scrofa | |
| 0.035 | - |
Inositol 1,3,4,5,6-pentakisphosphate | with inositol 1,3,4,5-tetrakisphosphate as substrate | Sus scrofa | |
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