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Literature summary for 3.1.3.56 extracted from
- Kinetic and inhibitor profiles of soluble and particulate inositol 1,4-5-trisphosphate 5-phosphatase from GH3 and IMR-32 cells (1990), Biochem. J., 271, 735-742.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2,3-bisphosphoglycerate | - |
Homo sapiens |  |
| 2,3-bisphosphoglycerate | - |
Rattus norvegicus | |
| CdCl2 | - |
Homo sapiens | |
| CdCl2 | - |
Rattus norvegicus | |
| D-fructose 1,6-bisphosphate | - |
Homo sapiens | |
| D-fructose 1,6-bisphosphate | - |
Rattus norvegicus | |
| D-fructose 2,6-bisphosphate | - |
Homo sapiens | |
| D-fructose 2,6-bisphosphate | - |
Rattus norvegicus | |
| D-glucose 6-phosphate | - |
Homo sapiens | |
| D-glucose 6-phosphate | - |
Rattus norvegicus | |
| Inositol 1,3,4,5-tetrakisphosphate | - |
Homo sapiens | |
| Inositol 1,3,4,5-tetrakisphosphate | - |
Rattus norvegicus | |
| p-hydroxymercuribenzoate | - |
Homo sapiens | |
| p-hydroxymercuribenzoate | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | major part of activity is membrane bound | Homo sapiens | 16020 | - |
| membrane | major part of activity is membrane bound | Rattus norvegicus | 16020 | - |
| soluble | two different soluble enzymes, type I and type II | Homo sapiens | - |
- |
| soluble | two different soluble enzymes, type I and type II | Rattus norvegicus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-myo-inositol 1,4,5-trisphosphate + H2O | Homo sapiens | regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate | D-myo-inositol 1,4-bisphosphate + phosphate | - |
? | |
| D-myo-inositol 1,4,5-trisphosphate + H2O | Rattus norvegicus | regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate | D-myo-inositol 1,4-bisphosphate + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
IMR-32 neuroblastoma cells | - |
| Rattus norvegicus | - |
GH3 pituitary cells | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cerebral cortex | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-myo-inositol 1,4,5-trisphosphate + H2O | - |
Homo sapiens | D-myo-inositol 1,4-bisphosphate + phosphate | - |
? | |
| D-myo-inositol 1,4,5-trisphosphate + H2O | - |
Rattus norvegicus | D-myo-inositol 1,4-bisphosphate + phosphate | - |
? | |
| D-myo-inositol 1,4,5-trisphosphate + H2O | regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate | Homo sapiens | D-myo-inositol 1,4-bisphosphate + phosphate | - |
? | |
| D-myo-inositol 1,4,5-trisphosphate + H2O | regulation of intracellular Ca2+ level by degradation of intracellular Ca2+ releasing second messenger D-myo-inositol 1,4,5-trisphosphate | Rattus norvegicus | D-myo-inositol 1,4-bisphosphate + phosphate | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
- |
Homo sapiens |
| 7 | - |
- |
Rattus norvegicus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6.25 | 8.25 | - |
Homo sapiens |
| 6.25 | 8.25 | - |
Rattus norvegicus |
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