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Literature summary for 3.1.3.56 extracted from

  • Ijuin, T.; Hosooka, T.; Takenawa, T.
    Phosphatidylinositol 3,4,5-trisphosphate phosphatase SKIP links endoplasmic reticulum stress in skeletal muscle to insulin resistance (2016), Mol. Cell. Biol., 36, 108-118 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.56

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Mus musculus 5783
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O Mus musculus
-
 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
C2C12 cell
-
 Mus musculus
-
skeletal muscle
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O
-
 Mus musculus 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
PIP3 phosphatase
-
 Mus musculus
skeletal muscle kidney-enriched inositol polyphosphate phosphatase
-
 Mus musculus
SKIP
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus enzyme expression is increased due to endoplasmic reticulum stress and is higher in the skeletal muscle isolated from high-fat-diet-fed mice and db/db mice than in that from wild type mice. Enzyme protein expression is increased by the expression of transcription factors ATF6alpha and XBP1 up

General Information

General Information Comment Organism
physiological function the enzyme links endoplasmic reticulum stress to insulin resistance in skeletal muscle Mus musculus