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Literature summary for 3.1.3.52 extracted from

  • Damuni, Z.; Humphreys, J.S.; Reed, L.J.
    A potent, heat-stable protein inhibitor of [branched-chain alpha-keto acid dehydrogenase]-phosphatase from bovine kidney mitochondria (1986), Proc. Natl. Acad. Sci. USA, 83, 285-289.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
Inhibitor protein non competitive; purification of heat- and acid-stable inhibitor protein, which regulates activity Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Bos taurus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate + H2O Bos taurus
-
[3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
22.86
-
-
Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] phosphate + H2O
-
Bos taurus [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] + phosphate
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00000013
-
Inhibitor protein pH 7.3, 30°C Bos taurus