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Literature summary for 3.1.3.5 extracted from
- Purification of rat liver 5'-nucleotidase as a complex with sphingomyelin (1974), Methods Enzymol., 32, 368-374.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| adenosine | - |
Rattus norvegicus |  |
| Co2+ | 0.1 mM activate, 4 mM inhibit, plasma membrane enzyme | Rattus norvegicus | |
| EDTA | - |
Rattus norvegicus | |
| Fe2+ | plasma membrane enzyme | Rattus norvegicus | |
| Mn2+ | 0.1 mM activate, 4 mM inhibit, plasma membrane enzyme | Rattus norvegicus | |
| Ni2+ | plasma membrane enzyme | Rattus norvegicus | |
| Pb2+ | plasma membrane enzyme | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| Golgi apparatus | - |
Rattus norvegicus | 5794 | - |
| microsome | - |
Rattus norvegicus | - |
- |
| mitochondrial membrane | - |
Rattus norvegicus | 31966 | - |
| plasma membrane | - |
Rattus norvegicus | 5886 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Co2+ | 0.1 mM activates, 4 mM inhibits, plasma membrane enzyme | Rattus norvegicus | |
| Mg2+ | activation, membrane-bound enzyme | Rattus norvegicus | |
| Mn2+ | 0.1 mM activates, 4 mM inhibits, plasma membrane enzyme | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| liver, membrane-bound | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | membrane-bound | Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 124 | - |
- |
Rattus norvegicus |
Storage Stability
| Storage Stability | Organism |
|---|---|
| 0°C, 0.1 M Tris-HCl, pH 7.5, 1 mM MgCl2, 1 mM 5'-AMP, stable for 3 months | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5'-AMP + H2O | - |
Rattus norvegicus | adenosine + phosphate | - |
? | |
| 5'-CMP + H2O | - |
Rattus norvegicus | cytidine + phosphate | - |
? | |
| 5'-UMP + H2O | - |
Rattus norvegicus | uridine + phosphate | - |
? | |
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Release 2023.1 (January 2023)
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