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Literature summary for 3.1.3.5 extracted from

  • Yu, J.; Wang, X.; Lu, Q.; Wang, J.; Li, L.; Liao, X.; Zhu, W.; Lv, L.; Zhi, X.; Yu, J.; Jin, Y.; Zou, Q.; Ou, Z.; Liu, X.; Zhou, P.
    Extracellular 5'-nucleotidase (CD73) promotes human breast cancer cells growth through AKT/GSK-3beta/beta-catenin/cyclinD1 signaling pathway (2018), Int. J. Cancer, 142, 959-967 .
    View publication on PubMed
Search for more literature for 3.1.3.5

Inhibitors

Inhibitors Comment Organism Structure
alpha,beta-methylene-ADP specific inhibitor Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P21589
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
 Homo sapiens
-
BT-549 cell
-
 Homo sapiens
-
MCF-10A cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-
MDA-MB-231 cell
-
 Homo sapiens
-
T-47D cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5'-AMP + H2O
-
 Homo sapiens adenosine + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
5'-nucleotidase
-
 Homo sapiens
CD73
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the expression of the enzyme is high in breast cancer tissues and increases with advanced tumor grades and lympho-node status up

General Information

General Information Comment Organism
physiological function enzyme overexpression promotes breast cancer cell proliferation by stimulating the AKT/GSK-3beta/beta-catenin signal pathway Homo sapiens