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Literature summary for 3.1.3.5 extracted from

  • Cividini, F.; Filoni, D.N.; Pesi, R.; Allegrini, S.; Camici, M.; Tozzi, M.G.
    IMP-GMP specific cytosolic 5'-nucleotidase regulates nucleotide pool and prodrug metabolism (2015), Biochim. Biophys. Acta, 1850, 1354-1361 .
    View publication on PubMed
Search for more literature for 3.1.3.5

Inhibitors

Inhibitors Comment Organism Structure
beta-gamma-methylene-ATP
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ 20 mM used in assay conditions Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5'-GMP + H2O Homo sapiens
-
 guanosine + phosphate
-
 r
5'-IMP + H2O Homo sapiens best substrate inosine + phosphate
-
 r

Organism

Organism UniProt Comment Textmining
Homo sapiens P49902
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-
HKiG2 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5'-GMP + H2O
-
 Homo sapiens guanosine + phosphate
-
 r
5'-IMP + H2O
-
 Homo sapiens inosine + phosphate
-
 r
5'-IMP + H2O best substrate Homo sapiens inosine + phosphate
-
 r
inosine + phosphate
-
 Homo sapiens 5'-IMP + H2O
-
 r

Synonyms

Synonyms Comment Organism
cN-II
-
 Homo sapiens
type II cytosolic 5'-nucleotidase
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the addition of ponasterone leads to overexpression of the enzyme assayed as phosphotransferase in an exposure time-dependent manner up