Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.3.5 extracted from

  • Iqbal, J.; Saeed, A.; Raza, R.; Matin, A.; Hameed, A.; Furtmann, N.; Lecka, J.; Sevigny, J.; Bajorath, J.
    Identification of sulfonic acids as efficient ecto-5-nucleotidase inhibitors (2013), Eur. J. Med. Chem., 70, 685-691.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1-amino-4-bromo-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid
-
Homo sapiens
1-amino-4-bromo-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid
-
Rattus norvegicus
4-(3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonic acid compound shows high cytotoxicity on H157 cells, with about 72% at 100 mM final concentration Homo sapiens
4-(3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonic acid
-
Rattus norvegicus
6-amino-4-hydroxynaphthalene-2-sulfonic acid most potent inhibitor of the screen Homo sapiens
6-amino-4-hydroxynaphthalene-2-sulfonic acid most potent inhibitor of the screen Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
ecto-5'-nucleotidase
-
Rattus norvegicus
-
ecto-5'-nucleotidase
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00132
-
pH 7.4, 37°C Homo sapiens 6-amino-4-hydroxynaphthalene-2-sulfonic acid
0.004
-
pH 7.4, 37°C Homo sapiens 1-amino-4-bromo-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid
0.0061
-
pH 7.4, 37°C Homo sapiens 4-(3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonic acid
0.0104
-
pH 7.4, 37°C Rattus norvegicus 6-amino-4-hydroxynaphthalene-2-sulfonic acid
0.027
-
pH 7.4, 37°C Rattus norvegicus 1-amino-4-bromo-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid
0.0443
-
pH 7.4, 37°C Rattus norvegicus 4-(3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonic acid