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Literature summary for 3.1.3.48 extracted from
- Novel prokaryotic expression of thioredoxin-fused insulinoma associated protein tyrosine phosphatase 2 (IA-2), its characterization and immunodiagnostic application (2016), BMC Biotechnol., 16, 84 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| recombinant expression of thioredoxin-fused insulinoma associated protein tyrosine phosphatase 2 (IA-2) in Escherichia coli strains GI698 and GI724 | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | development and evaluation of a method for production and recovery of the properly folded intracellular domain of IA-2 fused to thioredoxin (TrxIA-2ic) in Escherichia coli GI698 and GI724 strains, overview | Homo sapiens |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 55209 | 55943 | recombinant monomeric thioredoxin-fused enzyme, mass spectrometry | Homo sapiens |
| 64816 | - |
recombinant monomeric thioredoxin-fused enzyme, gel filtration | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q16849 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant thioredoxin-fused insulinoma associated protein tyrosine phosphatase 2 (IA-2) from Escherichia coli strains GI698 and GI724 by phenylarsine oxide-resin affinity chromatography | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | development and optimization of non-radiometric immunoassays for the efficient detection of IA-2 autoantibodies (IA-2A) | Homo sapiens | ? | - |
? |  |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 55209-55943, recombinant thioredoxin-fused enzyme, mass spectrometry | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| IA-2 | - |
Homo sapiens |
| IA-2A | - |
Homo sapiens |
| insulinoma associated protein tyrosine phosphatase 2 | - |
Homo sapiens |
| tyrosine phosphatase IA-2 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the insulinoma associated protein tyrosine phosphatase 2 (IA-2) is one of the immunodominant autoantigens involved in the autoimmune attack to the beta-cell in type 1 diabetes mellitus | Homo sapiens |
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Release 2023.1 (January 2023)
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