Cloned (Comment) | Organism |
---|---|
recombinant expression of thioredoxin-fused insulinoma associated protein tyrosine phosphatase 2 (IA-2) in Escherichia coli strains GI698 and GI724 | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | development and evaluation of a method for production and recovery of the properly folded intracellular domain of IA-2 fused to thioredoxin (TrxIA-2ic) in Escherichia coli GI698 and GI724 strains, overview | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
55209 | 55943 | recombinant monomeric thioredoxin-fused enzyme, mass spectrometry | Homo sapiens |
64816 | - |
recombinant monomeric thioredoxin-fused enzyme, gel filtration | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q16849 | - |
- |
Purification (Comment) | Organism |
---|---|
recombinant thioredoxin-fused insulinoma associated protein tyrosine phosphatase 2 (IA-2) from Escherichia coli strains GI698 and GI724 by phenylarsine oxide-resin affinity chromatography | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | development and optimization of non-radiometric immunoassays for the efficient detection of IA-2 autoantibodies (IA-2A) | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 55209-55943, recombinant thioredoxin-fused enzyme, mass spectrometry | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
IA-2 | - |
Homo sapiens |
IA-2A | - |
Homo sapiens |
insulinoma associated protein tyrosine phosphatase 2 | - |
Homo sapiens |
tyrosine phosphatase IA-2 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the insulinoma associated protein tyrosine phosphatase 2 (IA-2) is one of the immunodominant autoantigens involved in the autoimmune attack to the beta-cell in type 1 diabetes mellitus | Homo sapiens |