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Literature summary for 3.1.3.48 extracted from

  • Bae, D.; Camilli, T.C.; Chun, G.; Lal, M.; Wright, K.; OBrien, T.J.; Patierno, S.R.; Ceryak, S.
    Bypass of hexavalent chromium-induced growth arrest by a protein tyrosine phosphatase inhibitor: enhanced survival and mutagenesis (2009), Mutat. Res., 660, 40-46.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.48

Inhibitors

Inhibitors Comment Organism Structure
Cr(VI) as Na2CrO4, induces clonogenic lethality Homo sapiens
sodium orthovanadate a broad-range PTP inhibitor, abrogated Cr(VI)-induced clonogenic lethality Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast lung Homo sapiens
-
LL24 cell
-
 Homo sapiens
-
lung
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
protein tyrosine phosphatase
-
 Homo sapiens
PTP
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction PTPs are integral components of key cell survival pathways, and are responsible for their inactivation, while PTP inhibition is are often associated with enhanced cell proliferation, overview. PTP inhibition in the presence of certain types of DNA damage may lead to increased genomic instability, via bypass of cell cycle checkpoints Homo sapiens
physiological function PTPs are integral components of key cell survival pathways, and are responsible for their inactivation, while PTP inhibition is are often associated with enhanced cell proliferation, overview Homo sapiens