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Literature summary for 3.1.3.48 extracted from

  • Young, J.A.; Becker, A.M.; Medeiros, J.J.; Shapiro, V.S.; Wang, A.; Farrar, J.D.; Quill, T.A.; Hooft van Huijsduijnen, R.; van Oers, N.S.
    The protein tyrosine phosphatase PTPN4/PTP-MEG1, an enzyme capable of dephosphorylating the TCR ITAMs and regulating NF-kappaB, is dispensable for T cell development and/or T cell effector functions (2008), Mol. Immunol., 45, 3756-3766.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in insect cells and HEK-293T cells Mus musculus
expression in Jurkat cells Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
spleen
-
Mus musculus
-
testis
-
Mus musculus
-
thymus
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PTPN4 does not dephosphorylate Lck at tyrosine residue 394 Mus musculus ?
-
?
phosphorylated T-cell receptor-zeta subunit + H2O dephosphorylates ITAMs of the T-cell receptor-zeta subunit Mus musculus T-cell receptor-zeta subunit + phosphate
-
?

Synonyms

Synonyms Comment Organism
protein tyrosine phosphatase
-
Mus musculus
PTP
-
Mus musculus
PTPN4
-
Mus musculus
PTPN4/PTP-MEG1 a PTPH1-family member Mus musculus