Literature summary for 3.1.3.48 extracted from

Chang, Y.C.; Lin, S.Y.; Liang, S.Y.; Pan, K.T.; Chou, C.C.; Chen, C.H.; Liao, C.L.; Khoo, K.H.; Meng, T.C.
Tyrosine phosphoproteomics and identification of substrates of protein tyrosine phosphatase dPTP61F in Drosophila S2 cells by mass spectrometry-based substrate trapping strategy (2008), J. Proteome Res., 7, 1055-1066.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli BL21 DE3 cells	Drosophila melanogaster

Protein Variants

Protein Variants	Comment	Organism
C237S	catalytically dead mutant	Drosophila melanogaster
D203A	substrate-trapping mutant	Drosophila melanogaster

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	-	Drosophila melanogaster	16020	-
nucleus	-	Drosophila melanogaster	5634	-

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
61000	-	nucleus-localized enzyme form, calculated from amino acid sequence	Drosophila melanogaster
62100	-	membrane-localized enzyme form, calculated from amino acid sequence	Drosophila melanogaster

Organism

Organism	UniProt	Comment	Textmining
Drosophila melanogaster	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
Ni-NTA Sepharose column chromatography	Drosophila melanogaster

Source Tissue

Source Tissue	Comment	Organism	Textmining
S2 cell	-	Drosophila melanogaster	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
phosphorylated Abelson interacting protein + H2O	-	Drosophila melanogaster	Abelson interacting protein + phosphate	-	?
phosphorylated Abl tyrosine kinase + H2O	-	Drosophila melanogaster	Abl tyrosine kinase + phosphate	-	?
phosphorylated Ack protein + H2O	-	Drosophila melanogaster	Ack protein + phosphate	-	?
phosphorylated Down syndrome cell adhesion molecule + H2O	-	Drosophila melanogaster	Down syndrome cell adhesion molecule + phosphate	-	?
phosphorylated eukaryotic-initiation-factor-4G + H2O	-	Drosophila melanogaster	eukaryotic-initiation-factor-4G + phosphate	-	?
phosphorylated fragile X related + H2O	-	Drosophila melanogaster	fragile X related + phosphate	-	?
phosphorylated HEM protein + H2O	-	Drosophila melanogaster	HEM protein + phosphate	-	?
phosphorylated hepatocyte growth factor regulated tyrosine kinase substrate + H2O	-	Drosophila melanogaster	hepatocyte growth factor regulated tyrosine kinase substrate + phosphate	-	?
phosphorylated Hsc-70-4 + H2O	-	Drosophila melanogaster	Hsc-70-4 + phosphate	-	?
phosphorylated IGF-II mRNA-binding protein + H2O	-	Drosophila melanogaster	IGF-II mRNA-binding protein + phosphate	-	?
phosphorylated Lasp protein + H2O	-	Drosophila melanogaster	Lasp protein + phosphate	-	?
phosphorylated PDGF- and VEGF-receptor related + H2O	-	Drosophila melanogaster	PDGF- and VEGF-receptor related + phosphate	-	?
phosphorylated poly(A)-binding protein + H2O	-	Drosophila melanogaster	poly(A)-binding protein + phosphate	-	?
phosphorylated polychaetoid + H2O	-	Drosophila melanogaster	polychaetoid + phosphate	-	?
phosphorylated rasputin + H2O	-	Drosophila melanogaster	rasputin + phosphate	-	?
phosphorylated RhoGAP15B + H2O	-	Drosophila melanogaster	RhoGAP15B + phosphate	-	?
phosphorylated SCAR + H2O	-	Drosophila melanogaster	SCAR + phosphate	-	?
phosphorylated SH3PX1 + H2O	-	Drosophila melanogaster	SH3PX1 + phosphate	-	?
phosphorylated specifically Rac1-associated protein 1 + H2O	-	Drosophila melanogaster	specifically Rac1-associated protein 1 + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
dPTP61F	dPTP61F plays a central role in counteracting PTK-mediated signaling pathways as well as in regulating actin reorganization and remodeling through tyrosine dephosphorylation of critical substrates in Drosophila	Drosophila melanogaster
protein tyrosine phosphatase	-	Drosophila melanogaster
PTK	-	Drosophila melanogaster
PTP	-	Drosophila melanogaster

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Release 2023.1 (January 2023)