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Literature summary for 3.1.3.48 extracted from

  • Carlucci, A.; Gedressi, C.; Lignitto, L.; Nezi, L.; Villa-Moruzzi, E.; Avvedimento, E.V.; Gottesman, M.; Garbi, C.; Feliciello, A.
    Protein-tyrosine phosphatase PTPD1 regulates focal adhesion kinase autophosphorylation and cell migration (2008), J. Biol. Chem., 283, 10919-10929.
    View publication on PubMed
Search for more literature for 3.1.3.48

Protein Variants

Protein Variants Comment Organism
C1108S mutant lacks catalytic activity Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol PTPD1 localizes along actin filaments and at adhesion plaques Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens by modulating Src-focal adhesion kinase signaling at adhesion sites, PTPD1 promotes the cytoskeleton events that induce cell adhesion and migration ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
protein G-Sepharose chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information by modulating Src-focal adhesion kinase signaling at adhesion sites, PTPD1 promotes the cytoskeleton events that induce cell adhesion and migration Homo sapiens ?
-
 ?
phosphorylated actin + H2O
-
 Homo sapiens actin + phosphate
-
 ?
phosphorylated focal adhesion kinase + H2O dephosphorylation occurs at Tyr-397, PTPD1 activity is required for focal adhesion kinase autophosphorylation and adhesion plaque stability Homo sapiens focal adhesion kinase + phosphate
-
 ?
phosphorylated Src tyrosine kinase + H2O PTPD1 associates with and activates Src tyrosine kinase Homo sapiens Src tyrosine kinase + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
Protein-tyrosine phosphatase D1
-
 Homo sapiens
PTPD1 PTPD1 is a cytosolic nonreceptor tyrosine phosphatase and a positive regulator of the Src-epidermal growth factor transduction pathway Homo sapiens