Literature summary for 3.1.3.48 extracted from

Nakamura, Y.; Patrushev, N.; Inomata, H.; Mehta, D.; Urao, N.; Kim, H.W.; Razvi, M.; Kini, V.; Mahadev, K.; Goldstein, B.J.; McKinney, R.; Fukai, T.; Ushio-Fukai, M.
Role of protein tyrosine phosphatase 1B in vascular endothelial growth factor signaling and cell-cell adhesions in endothelial cells (2008), Circ. Res., 102, 1182-1191.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in HUVEC cells, overexpression of PTP1B stabilizes VE-cadherin-mediated cell-cell adhesions by reducing VE-cadherin tyrosine phosphorylation	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
C215S	the mutant is catalytically inactive	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
endothelial cell	-	Mus musculus	-
hindlimb	PTP1B protein is robustly increased in the ischemic hindlimb	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	phospho-p38 mitogen-activated protein kinase and Akt are not dephosphorylated	Mus musculus	?	-	?
phosphorylated ERK + H2O	dephosphorylation at Tyr-1175	Mus musculus	ERK + phosphate	-	?
phosphorylated phospholipase Cgamma + H2O	dephosphorylation occurs at Tyr-783	Mus musculus	phospholipase Cgamma + phosphate	-	?
phosphorylated vascular endothelial growth factor receptor 2 + H2O	dephosphorylation occurs at Tyr-1175, PTP1B binds to vascular endothelial growth factor receptor 2 cytoplasmic domain and directly dephosphorylates activated vascular endothelial growth factor receptor 2 immunoprecipitates	Mus musculus	vascular endothelial growth factor receptor 2 + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
protein tyrosine phosphatase 1B	-	Mus musculus
PTP1B	-	Mus musculus

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Release 2023.1 (January 2023)