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Literature summary for 3.1.3.47 extracted from
- Inactivation of rat liver HMG-CoA reductase phosphatases by polycarboxylic acids (1983), J. Lipid Res., 24, 821-830.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3-hydroxy-3-methylglutarate | - |
Rattus norvegicus |  |
| citrate | - |
Rattus norvegicus | |
| diphosphate | - |
Rattus norvegicus | |
| Maleate | - |
Rattus norvegicus | |
| malonate | - |
Rattus norvegicus | |
| oxalate | - |
Rattus norvegicus | |
| phosphate | - |
Rattus norvegicus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | activation, inactivation by chelators of divalent cations, metal bound at the catalytic site | Rattus norvegicus | |
| Mn2+ | activation, inactivation by chelators of divalent cations, metal bound at the catalytic site | Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 310000 | - |
cytosolic isoenzyme IIa, gel chromatography | Rattus norvegicus |
| 480000 | - |
cytosolic isoenzyme Ia, gel chromatography | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate + H2O | Rattus norvegicus | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| liver | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 310 | 315 | no comments on grade of purification, native cytosolic isoenzyme Ia | Rattus norvegicus |
| 670 | 710 | no comments on grade of purification, native cytosolic isoenzyme IIa | Rattus norvegicus |
| 21480 | - |
purification 4500fold, catalytic subunit of ~35000 Da after ethanol treatment | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glycogen synthase phosphate + H2O | - |
Rattus norvegicus | glycogen synthase + phosphate | - |
? | |
| phosphorylase a phosphate + H2O | - |
Rattus norvegicus | phosphorylase a + phosphate | - |
? | |
| [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate + H2O | - |
Rattus norvegicus | [hydroxymethylglutaryl-CoA reductase (NADPH)] + phosphate | - |
? | |
| [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate + H2O | - |
Rattus norvegicus | ? | - |
? | |
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Release 2023.1 (January 2023)
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