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Literature summary for 3.1.3.43 extracted from

  • Bak, C.I.; Huh, J.W.; Hong, S.; Song, B.J.
    Noncompetitive, Ca(2+)-independent inhibition of pyruvate dehydrogenase phosphatase by fluphenazine (1999), Biochem. Mol. Biol. Int., 47, 1029-1037.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
chlorpromazine
-
Bos taurus
fluphenazine
-
Bos taurus
thioridazine
-
Bos taurus
triflupromazine
-
Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Bos taurus 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ cannot overcome inhibition by calmodulin antagonists Bos taurus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
50000
-
1 * 90000 + 1 * 50000, SDS-PAGE Bos taurus
90000
-
1 * 90000 + 1 * 50000, SDS-PAGE Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[pyruvate dehydrogenase (lipoamide)]-phosphate + H2O Bos taurus
-
?
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Bos taurus
-

Storage Stability

Storage Stability Organism
4°C Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[pyruvate dehydrogenase (lipoamide)]-phosphate + H2O
-
Bos taurus [pyruvate dehydrogenase (lipoamide)] + phosphate
-
ir
[pyruvate dehydrogenase (lipoamide)]-phosphate + H2O
-
Bos taurus ?
-
?

Subunits

Subunits Comment Organism
dimer 1 * 90000 + 1 * 50000, SDS-PAGE Bos taurus