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Literature summary for 3.1.3.43 extracted from
- Pyruvate dehydrogenase (1987), The Enzymes, 3rd Ed. (Boyer, P. D. , ed. ), 18, 77-95.
No PubMed abstract available
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | reverses NADH inhibition | Bos taurus |  |
| putrescine | - |
Bos taurus | |
| spermidine | - |
Bos taurus | |
| spermine | in presence of Mg2+ and Ca2+ | Bos taurus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| KCl | - |
Bos taurus | |
| NADH | - |
Bos taurus | |
| p-nitrophenylphosphate | - |
Bos taurus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0029 | - |
[Pyruvate dehydrogenase (lipoamide)]-phosphate | with Ca2+ | Bos taurus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Bos taurus | 5739 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | - |
Bos taurus | |
| Mg2+ | Km: 2 mM | Bos taurus | |
| Mn2+ | - |
Bos taurus | |
| Mn2+ | Km: 0.5 mM | Neurospora crassa | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 50000 | - |
1 * 97000 + 1 * 50000, SDS-PAGE, heterodimer | Bos taurus |
| 97000 | - |
1 * 97000 + 1 * 50000, SDS-PAGE, heterodimer | Bos taurus |
| 150000 | - |
sedimentation equilibrium and gel filtration | Bos taurus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| [pyruvate dehydrogenase (lipoamide)]-phosphate + H2O | Bos taurus | - |
? | - |
? | |
| [pyruvate dehydrogenase (lipoamide)]-phosphate + H2O | Neurospora crassa | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
overview | - |
| Neurospora crassa | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | - |
Bos taurus | - |
| kidney | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| [pyruvate dehydrogenase (lipoamide)]-phosphate + H2O | - |
Bos taurus | [pyruvate dehydrogenase (lipoamide)] + phosphate | - |
ir | |
| [pyruvate dehydrogenase (lipoamide)]-phosphate + H2O | - |
Neurospora crassa | [pyruvate dehydrogenase (lipoamide)] + phosphate | - |
ir | |
| [pyruvate dehydrogenase (lipoamide)]-phosphate + H2O | - |
Bos taurus | ? | - |
? | |
| [pyruvate dehydrogenase (lipoamide)]-phosphate + H2O | - |
Neurospora crassa | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 1 * 97000 + 1 * 50000, SDS-PAGE, heterodimer | Bos taurus |
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Release 2023.1 (January 2023)
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