Literature summary for 3.1.3.43 extracted from

Kono, M.; Yoshida, N.; Maeda, K.; Skinner, N.E.; Pan, W.; Kyttaris, V.C.; Tsokos, M.G.; Tsokos, G.C.
Pyruvate dehydrogenase phosphatase catalytic subunit 2 limits Th17 differentiation (2018), Proc. Natl. Acad. Sci. USA, 115, 9288-9293 .

Search for more literature for 3.1.3.43

Application

Application	Comment	Organism
medicine	pyruvate dehydrogenase phosphatase catalytic subunit PDP2 expression is decreased in memory Th17 T-cells from patients with systemic lupus erythematosus and forced expression of PDP2 in CD4+ T-cells from patients with systemic lupus erythematosus suppresses Th17 differentiation	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Mus musculus	-	-	-

Expression

Organism	Comment	Expression
Mus musculus	inducible cAMP early repressor ICER binds to the Pdp2 promoter and suppresses its expression	down

General Information

General Information	Comment	Organism
physiological function	forced expression of pyruvate dehydrogenase phosphatase catalytic subunit PDP2 in CD4+ cells reduces the in vitro Th17 T-cell differentiation, whereas shRNA-based suppression of PDP2 expression increases in vitro Th17 differentiation and augments experimental autoimmune encephalomyelitis	Homo sapiens
physiological function	glycolysis and lactate production in in vitro Th17-polarized T-cells is reduced and the expression of pyruvate dehydrogenase phosphatase catalytic subunit and Pdh enzyme activity are increased in Th17 cells from animals deficient for inducible cAMP early repressor/cAMP response element modulator ICER/CREM. ICER binds to the Pdp2 promoter and suppresses its expression	Mus musculus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)