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Literature summary for 3.1.3.43 extracted from

  • Chen, H.B.; Shen, J.; Ip, Y.T.; Xu, L.
    Identification of phosphatases for Smad in the BMP/DPP pathway (2006), Genes Dev., 20, 648-653.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.43

Application

Application Comment Organism
molecular biology pyruvate dehydrogenase phosphatase acts as a Smad phosphatase and plays a key role in decapentaplegic signalling pathways, reduced Smad1 dephosphorylation after neutralisation of PDP1 or PDP2 with SiRNA Drosophila melanogaster
molecular biology pyruvate dehydrogenase phosphatase acts as a Smad1 phosphatase and plays a key role in TGF-b signalling pathways Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in S2 cells as GFP-construct Drosophila melanogaster
GST-fusion protein, expression in S2 cell line Drosophila melanogaster

Protein Variants

Protein Variants Comment Organism
D93A loss of phosphatase activity Drosophila melanogaster

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Drosophila melanogaster 5829
-
mitochondrion
-
 Drosophila melanogaster 5739
-
nucleus
-
 Drosophila melanogaster 5634
-

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Drosophila melanogaster

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293T cell
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-
S2 cell
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[mothers against decapentaplegic]-phosphate + H2O PDP1 directly dephosphorylates mothers against decapentaplegic (MAD) and inhibits signal transduction of decapentaplegic (DPP) Drosophila melanogaster [mothers against decapentaplegic] + phosphate
-
 ?
[pyruvate dehydrogenase (acetyl-transferring)] phosphate + H2O
-
 Drosophila melanogaster [pyruvate dehydrogenase (acetyl-transferring)] + phosphate
-
 ?
[pyruvate dehydrogenase (acetyl-transferring)] phosphate + H2O
-
 Homo sapiens [pyruvate dehydrogenase (acetyl-transferring)] + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
PDP
-
 Drosophila melanogaster
PDP1
-
 Drosophila melanogaster
PDP1
-
 Homo sapiens
PDP2
-
 Homo sapiens
pyruvate dehydrogenase phosphatase
-
 Drosophila melanogaster
pyruvate dehydrogenase phosphatase
-
 Homo sapiens
[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase
-
 Drosophila melanogaster
[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase
-
 Homo sapiens