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Literature summary for 3.1.3.43 extracted from

  • Patel, M.S.; Korotchkina, L.G.
    The biochemistry of the pyruvate dehydrogenase complex (2003), Biochem. Mol. Biol. Educ., 31, 5-15.
No PubMed abstract available
Search for more literature for 3.1.3.43

Activating Compound

Activating Compound Comment Organism Structure
spermine activates Mammalia

Application

Application Comment Organism
medicine overview, role of enzyme in diabetes and starvation Mammalia

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ activates, facilitates binding to substrate Mammalia
Mg2+ required, PDP2 is less sensitive to Mg2+ concentration than PDP1 Mammalia

Organism

Organism UniProt Comment Textmining
Mammalia
-
 isoforms PDP1, PDP2
-

Reaction

Reaction Comment Organism Reaction ID
[pyruvate dehydrogenase (acetyl-transferring)] phosphate + H2O = [pyruvate dehydrogenase (acetyl-transferring)] + phosphate mechanism, overview Mammalia
a

Source Tissue

Source Tissue Comment Organism Textmining
adipose tissue high level of PDP2 Mammalia
-
liver high level of PDP2 Mammalia
-
skeletal muscle high level of PDP1 Mammalia
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[pyruvate dehydrogenase (lipoamide)]-phosphate + H2O
-
 Mammalia [pyruvate dehydrogenase (lipoamide)] + phosphate
-
 ?

Subunits

Subunits Comment Organism
heterodimer catalytic subunit beloging to the phosphatase 2C class plus regulatory subunit, a flavoprotein, overview, there are two isoforms of the catalytic subunit+++ Mammalia

Synonyms

Synonyms Comment Organism
PDP
-
 Mammalia
PDP1
-
 Mammalia
PDP2
-
 Mammalia