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Literature summary for 3.1.3.4 extracted from
- Phosphatidic acid phosphatase, a key enzyme in the regulation of lipid synthesis (2009), J. Biol. Chem., 284, 2593-2597 .
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| cardiolipin | - |
Saccharomyces cerevisiae |  |
| CDP-diacylglycerol | - |
Saccharomyces cerevisiae | |
| phosphatidylinositol | - |
Saccharomyces cerevisiae | |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| D398E | inactive | Saccharomyces cerevisiae |
| D400E | inactive | Saccharomyces cerevisiae |
| G80R | inactive | Saccharomyces cerevisiae |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Saccharomyces cerevisiae | 5829 | - |
| membrane | - |
Saccharomyces cerevisiae | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | dependent on | Saccharomyces cerevisiae | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1,2-diacylglycerol 3-phosphate + H2O | Saccharomyces cerevisiae | - |
1,2-diacyl-sn-glycerol + phosphate | - |
ir | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | the enzyme is phosphorylated by cyclin-dependent kinase 1 | Saccharomyces cerevisiae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1,2-diacylglycerol 3-phosphate + H2O | - |
Saccharomyces cerevisiae | 1,2-diacyl-sn-glycerol + phosphate | - |
ir | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 124000, SDS-PAGE | Saccharomyces cerevisiae |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 3-sn-phosphatidate phosphohydrolase | - |
Saccharomyces cerevisiae |
| lipin | - |
Saccharomyces cerevisiae |
| PA2 phosphatase | - |
Saccharomyces cerevisiae |
| pah1 | - |
Saccharomyces cerevisiae |
| PAP3 | - |
Saccharomyces cerevisiae |
| SMP2 | - |
Saccharomyces cerevisiae |
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Release 2023.1 (January 2023)
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