Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
sphingosine-1-phosphate + H2O | Homo sapiens | - |
sphingosine + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O14495 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
aortic endothelial cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
sphingosine-1-phosphate + H2O | - |
Homo sapiens | sphingosine + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
lipid phosphate phosphatase 3 | - |
Homo sapiens |
LPP3 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | LPP3 expression is negatively correlated with vascular endothelial growth factor expression | down |
General Information | Comment | Organism |
---|---|---|
malfunction | LPP3 silencing in human primary aortic endothelial cells enhances secretion of inflammatory cytokines, leucocyte adhesion, cell survival, and migration and impairs angiogenesis, whereas wild-type LPP3 overexpression reversed these effects and induces apoptosis | Homo sapiens |
physiological function | LPP3 is a negative regulator of inflammatory cytokines, leucocyte adhesion, cell survival, and migration in human primary aortic endothelial cells, suggesting a protective role of LPP3 against endothelial dysfunction in humans | Homo sapiens |