Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | dephosphorylation of lipin Pah1p by the Nem1p-Spo7p complex enables the amphipathic helix to anchor Pah1p onto the nuclear/endoplasmic reticulum membrane allowing the production of diacylglycerol for lipid biosynthesis | Saccharomyces cerevisiae |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.43 | - |
phosphatidic acid | wild type enzyme, pH and temperature not specified in the publication | Saccharomyces cerevisiae |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | recruitment of the yeast lipin (Pah1p) is regulated by PA levels onto the nuclear/endoplasmic reticulum membrane. Recruitment requires the transmembrane protein phosphatase complex Nem1p-Spo7p | Saccharomyces cerevisiae | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | dependent on | Saccharomyces cerevisiae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Purification (Comment) | Organism |
---|---|
PtA fusion affinity purification | Saccharomyces cerevisiae |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphatidic acid + H2O | - |
Saccharomyces cerevisiae | 1,2-diacyl-sn-glycerol + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
lipin | - |
Saccharomyces cerevisiae |
PA phosphatase | - |
Saccharomyces cerevisiae |
Pah1p | - |
Saccharomyces cerevisiae |
General Information | Comment | Organism |
---|---|---|
physiological function | lipins are essential regulators of fat metabolism, adipogenesis, and organelle biogenesis | Saccharomyces cerevisiae |