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Literature summary for 3.1.3.4 extracted from

  • Zhang, P.; OLoughlin, L.; Brindley, D.N.; Reue, K.
    Regulation of lipin-1 gene expression by glucocorticoids during adipogenesis (2008), J. Lipid Res., 49, 1519-1528.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.3.4

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
140000
-
 Western blotting Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
 C57BL/6J and ob/ob mice
-

Source Tissue

Source Tissue Comment Organism Textmining
3T3-L1 cell
-
 Mus musculus
-
adipocyte
-
 Mus musculus
-
adipocyte
-
 Homo sapiens
-
HEPA 1-6 cell
-
 Mus musculus
-
hepatocyte
-
 Mus musculus
-
preadipocyte
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
lipin-1
-
 Mus musculus
lipin-1
-
 Homo sapiens
phosphatidic acid phosphatase-1
-
 Mus musculus
phosphatidic acid phosphatase-1
-
 Homo sapiens

Expression

Organism Comment Expression
Mus musculus lipin-1 gene expression is regulated in a glucocorticoid receptor-dependent manner additional information
Homo sapiens lipin-1 gene expression is regulated in a glucocorticoid receptor-dependent manner additional information
Mus musculus lipin-1A and -B expression levels increase dramatically during differentiation of 3T3-L1 preadipocytes to mature adipocytes. Glucocorticoids are the stimulus for the induction of lipin-1 expression in differentiating adipocytes. Lpin1 glucocorticoid response element binds to the glucocorticoid receptor and leads to transcriptional activation in adipocytes and hepatocytes. The Lpin1 promoter directly binds the glucocorticoid receptor in a hormone-dependent manner. Dexamethasone rapidly induces lipin-1 gene expression in a dose-dependent manner, it acts at the level of lipin-1 gene transcription. In response to 0.001 mM dexamethasone treatment, lipin-1B mRNA levels increase as early as 1 h, and lipin-1A levels after 2 h, whereby lipin-1B levels peak with a 7fold induction at 2 h and lipin-1A levels increase to a maximum of 3fold above baseline and remain elevated near this level throughout 24 h. Adipose tissue lipin-1 expression is increased in conditions associated with increased local glucocorticoid concentrations in vivo up
Homo sapiens total lipin-1 mRNA expression is significantly induced by dexamethasone in human preadipocytes and differentiated adipocytes up

General Information

General Information Comment Organism
physiological function lipin-1 may be a mediator of glucocorticoid effects in conditions such as fasting and obesity, genetic variations in this response may contribute to interindividual variations in lipin-1 expression levels. Glucocorticoid-induced Lpin1 regulation leads to increased protein and PAP1 activity Mus musculus