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Literature summary for 3.1.3.4 extracted from
- Inactivation of the C. elegans lipin homolog leads to ER disorganization and to defects in the breakdown and reassembly of the nuclear envelope (2009), J. Cell Sci., 122, 1970-1978.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| lpin-1 coding sequences (with introns) and 3' UTR sequences amplified and recombined into pDONR P1P3. Final product pAG-107 reacted with pCR319 (contains the unc-119(+) gene for transformation rescue of unc-119(ed3) mutants) and pAG-108 (including the lpin-1 promoter) to produce pAG-126 | Caenorhabditis elegans |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Caenorhabditis elegans | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| lipin | - |
Caenorhabditis elegans |
| phosphatidic acid phosphohydrolase | - |
Caenorhabditis elegans |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Caenorhabditis elegans | downregulation of LPIN-1 by RNAi | down |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | downregulating LPIN-1 by RNAi results in the appearance of membrane sheets and other abnormal structures in the peripheral endoplasmic reticulum. Lpin-1 RNAi causes defects in nuclear envelope breakdown, abnormal chromosome segregation and irregular nuclear morphology. RNAi of lipin results in reduced body size and defects in lipid storage | Caenorhabditis elegans |
| physiological function | lipin is needed for lipid storage and development. Lipin activity is needed for normal nuclear structure in dividing cells | Caenorhabditis elegans |
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