Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | is N-ethylmaleimide insensitive | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
LPP1, LPP2 and LPP3 | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
R127K/H223L | negligible LPP1 activity, although each mutant is still able to form oligomers | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | LPPs are integral membrane proteins with six transmembrane domains | Homo sapiens | 16020 | - |
additional information | LPP1 and LPP3 are present in caveolae, localised to distinct lipid rafts | Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
additional information | is Mg2+ independent | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
- |
- |
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
central nervous system | - |
Drosophila melanogaster | - |
embryonic fibroblast | - |
Mus musculus | - |
posterior midgut | - |
Drosophila melanogaster | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ceramide 1-phosphate + H2O | - |
Homo sapiens | ceramide + phosphate | - |
? | |
lysophosphatidic acid + H2O | - |
Homo sapiens | monoacylglycerol + phosphate | - |
? | |
additional information | the catalytic site is arranged into three distinct domains: one substrate recognition site and two catalytic sites | Homo sapiens | ? | - |
? | |
phosphatidic acid + H2O | - |
Homo sapiens | 1,2-diacyl-sn-glycerol + phosphate | - |
? | |
sphingosine 1-phosphate + H2O | - |
Homo sapiens | sphingosine + phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | catalytic activity is required for dimerisation | Drosophila melanogaster |
hexamer | - |
Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
lipid phosphate phosphatase | - |
Drosophila melanogaster |
lipid phosphate phosphatase | - |
Mus musculus |
lipid phosphate phosphatase | - |
Homo sapiens |
LPP1 | - |
Mus musculus |
LPP1 | - |
Homo sapiens |
LPP2 | - |
Homo sapiens |
LPP3 | - |
Homo sapiens |
Wunen | - |
Drosophila melanogaster |
wunen-2 | - |
Drosophila melanogaster |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | epidermal growth factor increases LPP3 mRNA in HeLa cells. Androgen increases LPP1 mRNA in adenocarcinoma cells | up |
General Information | Comment | Organism |
---|---|---|
physiological function | physiologically relevant increases in LPP1 activity in mouse embryonic fibroblasts (isolated from transgenic mice with 20 gene copies of LPP1) reduces lysophosphatidic acid- and platelet-derived growth factor-activation of ERK-1/2 and migration, resulting from down-regulation of typical proteinkinase C isoform(s) which are required for regulation of cell migration | Mus musculus |
physiological function | stable overexpression of LPP1 or LPP2 reduces sphingosine 1-phosphate, lysophosphatidic acid- and thrombin-induced activation of ERK-1/2 | Homo sapiens |
physiological function | wunen generates a phospholipid gradient and thereby repels germ cells towards higher phospholipid levels and away from the midline. Wunen/wunen-2 also governs the death of mis-migrating germ cells and survival of pole cells which compete for a common phospholipid substrate with somatic cells | Drosophila melanogaster |