Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | hyperactivated TORC2 enhances expression of lipin1. Diet-induced or genetic obesity increases LIPIN1 expression in mouse liver, and TORC2 is responsible for its transcriptional activation | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | overexpression of LIPIN1 disturbs hepatic insulin signaling, knockdown of LIPIN1 ameliorates hyperglycemia and insulin resistance by reducing diacylglycerol and PKC3 activity in db/db mice. TORC2-mediated insulin resistance is partially rescued by concomitant knockdown of LIPIN1, overview | Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
a 3-sn-phosphatidate + H2O | Mus musculus | lipin-1 plays a critical role in the perturbation of hepatic insulin signaling | a 1,2-diacyl-sn-glycerol + phosphate | - |
? | |
additional information | Mus musculus | hyperactivation of TORC2 exacerbates insulin resistance by enhancing expression of LIPIN1, a mammalian phosphatidic acid phosphatase for diacylglycerol synthesis, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
gene LIPIN1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
a 3-sn-phosphatidate + H2O | - |
Mus musculus | a 1,2-diacyl-sn-glycerol + phosphate | - |
? | |
a 3-sn-phosphatidate + H2O | lipin-1 plays a critical role in the perturbation of hepatic insulin signaling | Mus musculus | a 1,2-diacyl-sn-glycerol + phosphate | - |
? | |
additional information | hyperactivation of TORC2 exacerbates insulin resistance by enhancing expression of LIPIN1, a mammalian phosphatidic acid phosphatase for diacylglycerol synthesis, overview | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
lipin-1 | - |
Mus musculus |
phosphatidic acid phosphatase | - |
Mus musculus |